ArticleExperimental and clinical psychopharmacology2008
Effects of a context shift and multiple context extinction on reactivity to alcohol cues.
Article in Experimental and clinical psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Context Memory Discrimination and Recognition in Humans: Development of a Novel Cognitive Task.JMIR formative research · 2026Article
- Exploring neural markers of incentive salience and real-world drinking among individuals with alcohol use disorder.Physiology & behavior · 2026Article
- Examining definitions and cues associated with alcohol-free and low-alcohol drinks.Addiction (Abingdon, England) · 2026Article
- Evidence for incentive salience sensitization as a pathway to alcohol use disorder.Neuroscience and biobehavioral reviews · 2019Review
- Article
- Extinction of Conditioned Responses to Methamphetamine-Associated Stimuli in Healthy Humans.Psychopharmacology · 2016Article
- Article
- D-cycloserine to enhance extinction of cue-elicited craving for alcohol: a translational approach.Translational psychiatry · 2015Article
- Can fear extinction be enhanced? A review of pharmacological and behavioral findings.Brain research bulletin · 2014Review
- Mindfulness as a strategy for coping with cue-elicited cravings for alcohol: an experimental examination.Alcoholism, clinical and experimental research · 2014Article
- The contextual brain: implications for fear conditioning, extinction and psychopathology.Nature reviews. Neuroscience · 2013Review
- Is talk "cheap"? An initial investigation of the equivalence of alcohol purchase task performance for hypothetical and actual rewards.Alcoholism, clinical and experimental research · 2012Article
- Factor Structure Validation of the Alcohol Dependence Scale in a Heavy Drinking College Sample.Journal of psychopathology and behavioral assessment · 2011Article
- Pharmacological enhancement of drug cue extinction learning: translational challenges.Annals of the New York Academy of Sciences · 2011Review
- Glutamatergic targets for enhancing extinction learning in drug addiction.Current neuropharmacology · 2010Article
- Extinction of drug- and withdrawal-paired cues in animal models: relevance to the treatment of addiction.Neuroscience and biobehavioral reviews · 2010Article
- The Potent Effect of Environmental Context on Relapse to Alcohol-Seeking After Extinction.The open addiction journal · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Cue exposure treatment (CET) attempts to reduce the influence of conditioned substance cues on addictive behavior via extinction, but has received only modest empirical support in clinical trials. This may be because extinction learning appears to be context dependent and a change in context may result in a return of conditioned responding (i.e., renewal), although this has received only limited empirical examination. The current study used a 4-session laboratory analogue of CET to examine whether a change in context following 3 sessions of alcohol cue exposure with response prevention would result in renewal of conditioned responding. In addition, this study examined whether conducting extinction in multiple contexts would attenuate renewal of conditioned responding. In one-way between-subjects design, 73 heavy drinkers (71% men) were randomized to 3 conditions: (a) single context extinction (extinction to alcohol cues in the same context for 3 sessions followed by a context shift at the fourth session), (b) multiple context extinction (extinction to alcohol cues in different contexts each day for all 4 sessions), and (c) pseudoextinction control condition (exposure to neutral cues in the same context for 3 sessions followed by exposure to alcohol cues at the fourth session). The results revealed the predicted cue reactivity and extinction effects, but the hypotheses that a context shift would generate renewed cue reactivity and that multiple contexts would enhance extinction were not supported. Methodological aspects of the study and the need for parametric data on the context dependency of extinction to alcohol cues are discussed.
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