ArticleBehavioral neuroscience2008
Sexually dimorphic enhancement by estradiol of male urinary odor detection thresholds in mice.
Article in Behavioral neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Alterations in odor hedonics in the 5XFAD Alzheimer's disease mouse model and the influence of sex.Behavioral neuroscience · 2020Article
- Deficits in olfactory sensitivity in a mouse model of Parkinson's disease revealed by plethysmography of odor-evoked sniffing.Scientific reports · 2020Article
- Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb.Journal of Parkinson's disease · 2020Article
- CPEB4-Dependent Neonate-Born Granule Cells Are Required for Olfactory Discrimination.Frontiers in behavioral neuroscience · 2019Article
- Gonadal hormones, but not sex, affect the acquisition and maintenance of a Go/No-Go odor discrimination task in mice.Hormones and behavior · 2018Article
- Effect of Ovarian Hormones and Mating Experience on the Preference of Female Mice to Investigate Male Urinary Pheromones.Chemical senses · 2018Article
- Differences in peripheral sensory input to the olfactory bulb between male and female mice.Scientific reports · 2017Article
- Hormonal gain control of a medial preoptic area social reward circuit.Nature neuroscience · 2017Article
- Brain Injury Alters Volatile Metabolome.Chemical senses · 2016Article
- Estrogens, androgens and generalized behavioral arousal in gonadectomized female and male C57BL/6 mice.Physiology & behavior · 2015Article
- Sex differences in the brain: a whole body perspective.Biology of sex differences · 2015Review
- A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.Brain : a journal of neurology · 2013Article
- Influence of Iron Deficiency on Olfactory Behavior in Weanling Rats.Journal of behavioral and brain science · 2012Article
- Respiratory and sniffing behaviors throughout adulthood and aging in mice.Behavioural brain research · 2011Article
- Estrogen-induced sexual incentive motivation, proceptivity and receptivity depend on a functional estrogen receptor alpha in the ventromedial nucleus of the hypothalamus but not in the amygdala.Neuroendocrinology · 2010Article
- Sexual differentiation of pheromone processing: links to male-typical mating behavior and partner preference.Hormones and behavior · 2009Review
- Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat.Journal of neurophysiology · 2009Article
- Sniffing behavior of mice during performance in odor-guided tasks.Chemical senses · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We asked whether sex and adult estrogen exposure influence the detection thresholds for urinary odors used by mice to guide their social behaviors. Gonadectomized (GDX) male and female mice were trained on a two-choice food-motivated task to determine detection thresholds for male urinary odors. There was no significant sex difference in the detection of these odors by GDX subjects without hormone replacement. However, during treatment with estradiol benzoate (EB), GDX females, but not GDX males, showed an enhanced ability to detect these odors. To investigate a possible mechanism for this effect, the authors measured GDX females' odor-sampling behavior (sniffing) by monitoring intranasal pressure transients during performance of the urinary odor detection task with and without EB treatment. Under both hormone conditions, females decreased their sniffing frequency as the urinary odor concentration decreased, with this decrease being significantly greater while GDX females received EB. Thus, estradiol enhanced detection thresholds for male urine in a sex-specific manner, and this enhanced sensitivity in females was correlated with altered odor-sampling behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.