Evidence map›Paper›PMID 18729092›Full record

ArticleChemistry & biodiversity2008

Effects of vanadium-containing compounds on membrane lipids and on microdomains used in receptor-mediated signaling.

Deborah A Roess, Steven M L Smith, Peter Winter, Jun Zhou, Ping Dou, Bharat Baruah, Alejandro M Trujillo, Nancy E Levinger, Xioda Yang, B George Barisas and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Antidiabetic vanadium compound and membrane interfaces: interface-facilitated metal complex hydrolysis.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2011
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Deborah A RoessDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
Steven M L SmithDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
Peter WinterDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
Jun ZhouDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
Ping DouDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA.
Bharat BaruahDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
Alejandro M TrujilloDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
Nancy E LevingerDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
Xioda YangDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China.
B George BarisasDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
Debbie C CransDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
Colorado State University · USPeking University · CN

Funding

Development of Rotational Fluctuation Spectroscopy for Biological ApplicationsR21RR023156 · NCRR · COLORADO STATE UNIVERSITY · PI BARISAS, B. GEORGE · 2006 to 2008
$503k
NCRR NIH HHS R21 RR023156
6 · The paper itself

Abstract

There is increasing evidence for the involvement of plasma membrane microdomains in insulin receptor function. Moreover, disruption of these structures, which are typically enriched in sphingomyelin and cholesterol, results in insulin resistance. Treatment strategies for insulin resistance include the use of vanadium (V) compounds which have been shown in animal models to enhance insulin responsiveness. One possible mechanism for insulin-enhancing effects might involve direct effects of V compounds on membrane lipid organization. These changes in lipid organization promote the partitioning of insulin receptors and other receptors into membrane microdomains where receptors are optimally functional. To explore this possibility, we have used several strategies involving V complexes such as [VO(2)(dipic)](-) (pyridin-2,6-dicarboxylatodioxovanadium(V)), decavanadate (V(10)O(28)(6-), V(10)), BMOV (bis(maltolato)oxovanadium(IV)), and [VO(saltris)](2) (2-salicylideniminato-2-(hydroxymethyl)-1,3-dihydroxypropane-oxovanadium(V)). Our strategies include an evaluation of interactions between V-containing compounds and model lipid systems, an evaluation of the effects of V compounds on lipid fluidity in erythrocyte membranes, and studies of the effects of V-containing compounds on signaling events initiated by receptors known to use membrane microdomains as signaling platforms.

Indexed as

AnimalsCalciumCells, CulturedGlucose Transporter Type 4InsulinLigandsMagnetic Resonance SpectroscopyMembrane LipidsMembrane MicrodomainsMolecular StructureOrganometallic CompoundsRatsReceptor, InsulinReference StandardsSignal TransductionVanadiumCalciumGlucose Transporter Type 4InsulinLigandsMembrane LipidsOrganometallic CompoundsReceptor, InsulinSlc2a4 protein, ratVanadium

Identifiers

PMID18729092
PMCPMC3159192
OpenAlexW2011787700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.