ArticleJournal of cellular biochemistry2008
Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts.
Article in Journal of cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin-ATF4 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Irisin as an agent for protecting against osteoporosis: A review of the current mechanisms and pathways.Journal of advanced research · 2024Review
- Article
- Fluid Shear Stress Promotes Osteoblast Proliferation and Suppresses Mitochondrial-Mediated Osteoblast Apoptosis Through the miR-214-3p-ATF4 Signaling Axis.Physiological research · 2022Article
- Article
- Paracrine Kynurenic Pathway Activation in the Bone of Young Uremic Rats Can Antagonize Anabolic Effects of PTH on Bone Turnover and Strength through the Disruption of PTH-Dependent Molecular Signaling.International journal of molecular sciences · 2021Article
- Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice.Bone research · 2020Article
- microRNA-Mediated Regulation of Bone Remodeling: A Brief Review.JBMR plus · 2019Review
- MicroRNA-214 Suppresses Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting ATF4.Stem cells international · 2017Article
- Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis.Nature communications · 2015Article
- Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy.The Journal of biological chemistry · 2015Article
- Expression of a phosphorylated form of ATF4 in lung and non-small cell lung cancer tissues.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.The Journal of biological chemistry · 2013Article
- Article
- PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition.International journal of biological sciences · 2013Article
- atf4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells.International journal of biological sciences · 2013Article
- cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene.The Journal of biological chemistry · 2011Article
- Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts.The Journal of biological chemistry · 2011Article
- Activating transcription factor 4 regulates osteoclast differentiation in mice.The Journal of clinical investigation · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Activating transcription factor 4 (ATF4) is essential for bone formation. However, the mechanism of its actions in bone is poorly understood. The present study examined the role for ATF4 in the regulation of proliferation and survival of primary mouse bone marrow stromal cells (BMSCs) and osteoblasts. Results showed that Atf4(-/-) cells display a severe proliferative defect as measured by multiple cell proliferation assays. Cell cycle progression of Atf4(-/-) BMSCs was largely delayed with significant G1 arrest. Expression of cyclin D1 was decreased both at the mRNA and protein level. A similar proliferation defect was observed in Atf4(-/-) calvarial periosteal osteoblasts when compared with wt control. Knocking down Atf4 mRNA by small interfering RNA in MC3T3-E1 subclone 4 preosteoblasts markedly reduced expression of cyclin D1 and cell proliferation. In contrast, overexpression of ATF4 increased cyclin D1 expression as well as cell proliferation in Atf4(-/-) BMSCs. In addition, apoptosis was significantly increased in Atf4(-/-) BMSCs and calvarial periosteal osteoblasts relative to wt controls. Taken together, these results for the first time demonstrate that ATF4 is a critical regulator of proliferation and survival in BMSCs and osteoblasts in vitro and in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.