ArticlePloS one2008
Genetic architecture of hybrid male sterility in Drosophila: analysis of intraspecies variation for interspecies isolation.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Identification and genetic analysis of a pervasive 'needle-eye' sperm phenotype inProceedings. Biological sciences · 2024Article
- Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?Evolution; international journal of organic evolution · 2024Article
- Hybrid breakdown in male reproduction between recently diverged Drosophila melanogaster populations has a complex and variable genetic architecture.Evolution; international journal of organic evolution · 2023Article
- Transposable Element Expression and Regulation Profile in Gonads of Interspecific Hybrids ofCells · 2021Article
- Comparative transcriptomics between Drosophila mojavensis and D. arizonae reveals transgressive gene expression and underexpression of spermatogenesis-related genes in hybrid testes.Scientific reports · 2021Article
- A common suite of cellular abnormalities and spermatogenetic errors in sterile hybrid males inProceedings. Biological sciences · 2020Article
- Identification of misexpressed genetic elements in hybrids between Drosophila-related species.Scientific reports · 2017Article
- Environmentally induced changes in correlated responses to selection reveal variable pleiotropy across a complex genetic network.Evolution; international journal of organic evolution · 2015Article
- Article
- A novel approach identifying hybrid sterility QTL on the autosomes of Drosophila simulans and D. mauritiana.PloS one · 2013Article
- Mapping of within-species segregation distortion in Drosophila persimilis and hybrid sterility between D. persimilis and D. pseudoobscura.Journal of evolutionary biology · 2012Article
- Article
- Genetics of hybrid male sterility among strains and species in the Drosophila pseudoobscura species group.Evolution; international journal of organic evolution · 2011Article
- Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genetic basis of postzygotic isolation is a central puzzle in evolutionary biology. Evolutionary forces causing hybrid sterility or inviability act on the responsible genes while they still are polymorphic, thus we have to study these traits as they arise, before isolation is complete. METHODOLOGY/PRINCIPAL
findingsIsofemale strains of D. mojavensis vary significantly in their production of sterile F(1) sons when females are crossed to D. arizonae males. We took advantage of the intraspecific polymorphism, in a novel design, to perform quantitative trait locus (QTL) mapping analyses directly on F(1) hybrid male sterility itself. We found that the genetic architecture of the polymorphism for hybrid male sterility (HMS) in the F(1) is complex, involving multiple QTL, epistasis, and cytoplasmic effects. CONCLUSIONS/SIGNIFICANCE: The role of extensive intraspecific polymorphism, multiple QTL, and epistatic interactions in HMS in this young species pair shows that HMS is arising as a complex trait in this system. Directional selection alone would be unlikely to maintain polymorphism at multiple loci, thus we hypothesize that directional selection is unlikely to be the only evolutionary force influencing postzygotic isolation.
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