ReviewCell cycle (Georgetown, Tex.)2008
Protecting the stress response, guarding the MKP-1 mRNA.
Review in Cell cycle (Georgetown, Tex.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- The RNA-Binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH.Endocrinology · 2019Article
- Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes.Neuroscience · 2019Article
- MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability.Journal of experimental & clinical cancer research : CR · 2019Article
- Dual-Specificity Phosphatase Regulation in Neurons and Glial Cells.International journal of molecular sciences · 2019Review
- Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.International journal of molecular sciences · 2019Review
- Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.Archives of toxicology · 2019Article
- RNA binding proteins as regulators of immune cell biology.Clinical and experimental immunology · 2016Review
- Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- 5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability.Journal of neuroinflammation · 2012Article
- Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway.Journal of signal transduction · 2011Article
- Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?Journal of signal transduction · 2011Article
- Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells.Cell cycle (Georgetown, Tex.) · 2009Article
- Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation.Aging · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The RNA-binding protein (RBP) HuR plays a vital role in the mammalian stress response, effecting changes in the proliferation and survival of damaged cells. HuR prominently influences the stress response by regulating the stability and translation of mRNAs encoding stress-response proteins. Recently, HuR was found to affect mitogen-activated protein kinase (MAPK) signaling, at least in part by post-transcriptionally promoting the expression of MAPK phosphatase-1 (MKP-1). As anticipated for a pivotal regulator of the MAPKs c-jun N-terminal kinase (JNK) and p38, MKP-1 expression is tightly regulated transcriptionally, post-transcriptionally and post-translationally. HuR's influence on MKP-1 expression helps to ensure the appropriate abundance of MKP-1 and consequently the appropriate cellular response to stress stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.