Evidence map›Paper›PMID 18728233›Full record

ArticleDiabetes2008

Transplantation of bone marrow-derived mesenchymal stem cells improves diabetic polyneuropathy in rats.

Taiga Shibata, Keiko Naruse, Hideki Kamiya, Mika Kozakae, Masaki Kondo, Yutaka Yasuda, Nobuhisa Nakamura, Kimiko Ota, Takahiro Tosaki, Takashi Matsuki and 4 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02387749 (Effect Of Mesenchymal Stem Cells Transfusion on the Peripheral Neuropathy in Diabetic Patients Measured by Nerve Conduction.), which is not on this map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02387749 nacompletednot on this mapstarted 2014, after this paper: background citation

Effect Of Mesenchymal Stem Cells Transfusion on the Peripheral Neuropathy in Diabetic Patients Measured by Nerve Conduction.

TypeinterventionalSponsorCairo UniversityRan2014 to 2016Enrolled10ConditionsDiabetic Peripheral NeuropathyArmsmesenchymal stem cells
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 193 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Taiga ShibataDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Keiko Naruse
Hideki Kamiya
Mika Kozakae
Masaki Kondo
Yutaka Yasuda
Nobuhisa Nakamura
Kimiko Ota
Takahiro Tosaki
Takashi Matsuki
Eitaro Nakashima
Yoji Hamada
Yutaka Oiso
Jiro Nakamura
Nagoya University · JPAichi Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted to investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats. RESEARCH DESIGN AND

methodsMSCs were isolated from bone marrow of adult rats and transplanted into hind limb skeletal muscles of rats with an 8-week duration of streptozotocin (STZ)-induced diabetes or age-matched normal rats by unilateral intramuscular injection. Four weeks after transplantation, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) productions in transplanted sites, current perception threshold, nerve conduction velocity (NCV), sciatic nerve blood flow (SNBF), capillary number-to-muscle fiber ratio in soleus muscles, and sural nerve morphometry were evaluated.

resultsVEGF and bFGF mRNA expression were significantly increased in MSC-injected thigh muscles of STZ-induced diabetic rats. Furthermore, colocalization of MSCs with VEGF and bFGF in the transplanted sites was confirmed. STZ-induced diabetic rats showed hypoalgesia, delayed NCV, decreased SNBF, and decreased capillary number-to-muscle fiber ratio in soleus muscles, which were all ameliorated by MSC transplantation. Sural nerve morphometry showed decreased axonal circularity in STZ-induced diabetic rats, which was normalized by MSC transplantation.

conclusionsThese results suggest that MSC transplantation could have therapeutic effects on DPN through paracrine actions of growth factors secreted by MSCs.

Indexed as

AnimalsBone Marrow CellsCells, CulturedDiabetes Mellitus, ExperimentalDiabetic NeuropathiesEnzyme-Linked Immunosorbent AssayFibroblast Growth Factor 2MaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMuscle, SkeletalNerve Growth FactorNerve Growth FactorsRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionFibroblast Growth Factor 2Nerve Growth FactorNerve Growth Factorsneurotropin 3, mouseRNA, MessengerVascular Endothelial Growth Factor A

Identifiers

PMID18728233
PMCPMC2570407
OpenAlexW2141049046

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.