ArticlePhysiological genomics2008
Effect of starvation on transcriptomes of brain and liver in adult female zebrafish (Danio rerio).
Article in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Lipoprotein biology during induced oogenesis in the short-finned eel, Anguilla australis-hepatic target gene expression and accumulation of nutrient sources into developing oocytes.Fish physiology and biochemistry · 2026Article
- Integrated Histological and Transcriptomic Characterization of Prolonged Starvation Responses in the CavefishBiology · 2026Article
- Genome-wide copy number variation drives adaptive evolution inCurrent zoology · 2026Article
- Integrated transcriptomic and microbiota analyses reveal growth-related intestinal responses to feeding strategies in Nibea coibor.Advanced biotechnology · 2025Article
- Autophagy in aquatic animals: mechanisms, implications, and future directions.Frontiers in immunology · 2025Review
- The preferential utilization of hepatic glycogen as energy substrates in largemouth bass (Micropterus salmoides) under short-term starvation.Fish physiology and biochemistry · 2024Article
- Refeeding-associated AMPKNature aging · 2023Article
- The Interplay between Central and Peripheral Systems in Feed Intake Regulation in European Seabass (Animals : an open access journal from MDPI · 2022Article
- An Integrated Bioinformatics Approach to Identify Network-Derived Hub Genes in Starving Zebrafish.Animals : an open access journal from MDPI · 2022Article
- Gene Expression Profile Provides Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle.Nutrients · 2022Article
- Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding.BMC genomics · 2022Article
- Article
- Starvation Affects the Muscular Morphology, Antioxidant Enzyme Activity, Expression of Lipid Metabolism-Related Genes, and Transcriptomic Profile of Javelin Goby (Aquaculture nutrition · 2022Article
- Potential Roles of PTEN on Longevity in Two Closely RelatedFrontiers in physiology · 2022Article
- Revelation of candidate genes and molecular mechanism of reproductive seasonality in female rohu (Labeo rohita Ham.) by RNA sequencing.BMC genomics · 2021Article
- Feed Restriction Modulates Growth, Gut Morphology and Gene Expression in Zebrafish.International journal of molecular sciences · 2021Article
- Investigation of the Molecular Mechanisms of Antioxidant Damage and Immune Response Downregulation in Liver ofFrontiers in endocrinology · 2021Article
- Fermented Oyster Extract Promotes Insulin-Like Growth Factor-1-Mediated Osteogenesis and Growth Rate.Marine drugs · 2020Article
- Differential Proteomic Analysis of Chinese Giant Salamander Liver in Response to Fasting.Frontiers in physiology · 2020Article
- Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish (Danio rerio).BMC genomics · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We used microarray and quantitative real-time PCR (qRT-PCR) analyses in adult female zebrafish (Danio rerio) to identify metabolic pathways regulated by starvation in the liver and brain. The transcriptome of whole zebrafish brain showed little response to 21 days of starvation. Only agouti-related protein 1 (agrp1) significantly responded, with increased expression in brains of starved fish. In contrast, a 21-day period of starvation significantly downregulated 466 and upregulated 108 transcripts in the liver, indicating an overall decrease in metabolic activity, reduced lipid metabolism, protein biosynthesis, proteolysis, and cellular respiration, and increased gluconeogenesis. Starvation also regulated expression of many components of the unfolded protein response, the first such report in a species other than yeast (Saccharomyces cerevisiae) and mice (Mus musculus). The response of the zebrafish hepatic transcriptome to starvation was strikingly similar to that of rainbow trout (Oncorhynchus mykiss) and less similar to mouse, while the response of common carp (Cyprinus carpio) differed considerably from the other three species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.