ArticleProceedings of the National Academy of Sciences of the United States of America2008
Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Immune ageing at single-cell resolution.Nature reviews. Immunology · 2022Review
- OMIP-079: Cell cycle of CD4Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Article
- Age-Related Changes in Thymic Central Tolerance.Frontiers in immunology · 2021Review
- Functional recreation of age-related CD8 T cells in young mice identifies drivers of aging- and human-specific tissue pathology.Mechanisms of ageing and development · 2020Article
- Neutrophil: A New Player in Metastatic Cancers.Frontiers in immunology · 2020Review
- Characterization of age-associated exhausted CD8⁺ T cells defined by increased expression of Tim-3 and PD-1.Aging cell · 2016Article
- Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses.Experimental gerontology · 2013Article
- Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans.Journal of leukocyte biology · 2013Article
- Causes, consequences, and reversal of immune system aging.The Journal of clinical investigation · 2013Review
- Kidney transplantation and the ageing immune system.Nature reviews. Nephrology · 2012Review
- Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- TCR-dependent transformation of mature memory phenotype T cells in mice.The Journal of clinical investigation · 2011Article
- The narrowing of the CD8 T cell repertoire in old age.Current opinion in immunology · 2011Review
- Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model.Journal of Alzheimer's disease : JAD · 2010Article
- Diversity in T cell memory: an embarrassment of riches.Immunity · 2009Review
- Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
CD8 memory T cells are tightly regulated in young, healthy individuals but are often perturbed in aged animals by the appearance of large CD8 T cell clones. These clones are associated with impaired immunity in the aged. The molecular basis of this phenomenon remains unclear. Here, it is shown that the issue is confused by the fact that the clones are heterogeneous. Some clones bear high, and others, low levels of integrin alpha(4) (itgalpha4). These subtypes differ by multiple criteria. They appear in mice of different ages, concentrate in different tissues, and have different stabilities in vivo and responses to stimulation in vitro. itgalpha4(high), but not itgalpha4(low), CD8 clonal expansions have several characteristics consistent with a chronically stimulated phenotype. These properties include lowered levels of CD8, decreased expression of some cytokine receptors, and elevated expression of various inhibitory receptors, including the programmed death-1 (PD1) receptor and the killer cell lectin-like receptor G1 (KLRG1). The characteristics of itgalpha4(high) clonal expansions suggest that they may arise from age-dependent alterations in antigen expression and tolerance. These data redefine CD8 clonal expansions into at least two distinct entities and indicate that there are multiple mechanisms that drive age-related alterations of CD8 T cell homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.