ArticleThe Journal of clinical endocrinology and metabolism2008
Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche.
Article in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
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- A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates.Hormones and behavior · 2013Review
- Estrogen receptor α polymorphism in boys with constitutional delay of growth and puberty.Annals of pediatric endocrinology & metabolism · 2013Article
- The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA.Human genetics · 2011Article
- The transcriptional control of female puberty.Brain research · 2010Review
- A large-scale candidate gene association study of age at menarche and age at natural menopause.Human genetics · 2010Article
- Obesity and diabetes genetic variants associated with gestational weight gain.American journal of obstetrics and gynecology · 2010Article
- Genetic determinants of pubertal timing in the general population.Molecular and cellular endocrinology · 2010Review
- Gene networks and the neuroendocrine regulation of puberty.Molecular and cellular endocrinology · 2010Article
- Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples.PLoS genetics · 2010Article
- Decline in age at menarche among Spanish women born from 1925 to 1962.BMC public health · 2009Article
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
contextAlthough the timing of puberty is a highly heritable trait, little is known about the genes that regulate pubertal timing in the general population. Several genes have been identified that, when mutated, cause disorders of delayed or absent puberty such as hypogonadotropic hypogonadism (HH).
objectiveBecause severe variants in HH-related genes cause a severe puberty phenotype, we hypothesized that common subtle variation in these genes could contribute to the population variation in pubertal timing.
designWe assessed common genetic variation in 10 HH-related genes in 1801 women from the Hawaii and Los Angeles Multiethnic Cohort with either early (age<11 yr) or late (age>14 yr) menarche and in other replication samples. In addition to these common variants, we also studied the most frequently reported HH mutations to assess their role in the population variation in pubertal timing. SETTING AND PATIENTS/OTHER
participantsWithin the general community, 1801 women from the Hawaii and Los Angeles Multiethnic Cohort participated.
main outcome measuresWe assessed the association of genetic variation with age at menarche.
resultsWe found no significant association between any of the variants tested and age at menarche, although we cannot rule out modest effects of these variants or of other variants at long distances from the coding region. In several self-reported racial/ethnic groups represented in our study, we observed an association between estimated genetic ancestry and age at menarche.
conclusionsOur results suggest that common variants near 10 HH-related loci do not play a substantial role in the regulation of age at menarche in the general population.
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