ArticleNeural development2008
Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling.
Article in Neural development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Corticospinal Tract Development, Evolution, and Skilled Movements.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- Axon Fasciculation, Mediated by Transmembrane Semaphorins, Is Critical for the Establishment of Segmental Specificity of Corticospinal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Semaphorin 6A-Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons.iScience · 2019Article
- Skilled Movements in Mice Require Inhibition of Corticospinal Axon Collateral Formation in the Spinal Cord by Semaphorin Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.JCI insight · 2019Article
- The Spinal Transcriptome after Cortical Stroke: In Search of Molecular Factors Regulating Spontaneous Recovery in the Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2.Frontiers in molecular neuroscience · 2019Article
- Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.Neural development · 2017Article
- Characterization of Semaphorin 6A-Mediated Effects on Angiogenesis Through Regulation of VEGF Signaling.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Semaphorins and their Signaling Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology.PloS one · 2016Article
- One hand clapping: lateralization of motor control.Frontiers in neuroanatomy · 2015Review
- Plexin a4 expression in adult rat cranial nerves.Journal of chemical neuroanatomy · 2014Article
- Article
- PlexinA4 distribution in the adult rat spinal cord and dorsal root ganglia.Journal of chemical neuroanatomy · 2012Article
- Guidance of longitudinally projecting axons in the developing central nervous system.Frontiers in molecular neuroscience · 2012Article
- Semaphorin signaling in vertebrate neural circuit assembly.Frontiers in molecular neuroscience · 2012Article
- Segregation and pathfinding of callosal axons through EphA3 signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway. Several guidance molecules are known to be involved at various decision points to regulate the projection of CST axons. However, previous analyses of the CST guidance defects in mutant mice lacking these molecules have suggested that there are other molecules involved in CST axon guidance that are yet to be identified. In this study, we investigate the role of plexin signaling in the guidance of motor CST axons in vivo.
resultsExpression pattern studies show that plexin-A3, plexin-A4, and neuropilin-1 are expressed in the developing cerebral cortex when the motor CST axons originating from layer V cortical neurons are guided down to the spinal cord. By analyzing mutant mice, we show that motor CST axons that turn dorsally to cross the midline at the pyramidal decussation require plexin-A3 and plexin-A4 signaling. Although other CST guidance defects are found in neuropilin-1 mutants, this dorsal turning defect is not observed in either neuropilin-1 or neuropilin-2 mutants, suggesting that the local cues that activate plexin signaling at the dorsal turning point are membrane-bound semaphorins. Further expression pattern study and mutant analysis indicate that Sema6A is one of the local cues for motor CST axon turning at the pyramidal decussation.
conclusionDorsal turning and midline crossing at the pyramidal decussation is a crucial step to properly direct CST axons into the dorsal spinal cord. We show that the signaling of plexin-A3, plexin-A4, and Sema6A is at least partially required for dorsal turning of the CST axons, while neuropilin-1 is required for proper fasciculation of the tract at midline crossing. Together with previous reports, these results demonstrate that several guidance cues are specifically utilized to regulate the dorsal turning and midline crossing of developing CST axons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.