ArticleAnatomical record (Hoboken, N.J. : 2007)2008
Biglycan overexpression on tooth enamel formation in transgenic mice.
Article in Anatomical record (Hoboken, N.J. : 2007), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Biglycan in the Skeleton.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Review
- Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Characterization of natural, decellularized and reseeded porcine tooth bud matrices.Biomaterials · 2012Article
- Article
- Transgenic rescue of enamel phenotype in Ambn null mice.Journal of dental research · 2010Article
- The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition.The Journal of biological chemistry · 2010Article
- Consequences for enamel development and mineralization resulting from loss of function of ameloblastin or enamelin.European journal of oral sciences · 2009Article
- Reclaiming a natural beauty: whole-organ engineering with natural extracellular materials.Regenerative medicine · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Previously, it was shown that the volume of forming enamel of molar teeth in biglycan-null mice was greater than that in genetically matched wild-type mice. This phenotypic change appeared to result from an increase in amelogenin expression, implying that biglycan directly influences amelogenin synthesis. To determine whether biglycan overexpression resulted in decreased amelogenin expression, we engineered transgenic mice to overexpress biglycan in the enamel organ epithelium. Biglycan overexpression did not significantly affect the amelogenin expression in incisor and molar teeth in 3-day postnatal transgenic mice. In the transgenic animals, we observed that the immature and mature enamel appeared normal. These results suggested that increasing the biglycan expression, in the cells that synthesize the precursor protein matrix for enamel, has a negligible influence on amelogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.