ArticleDevelopmental neurobiology2008
Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates.
Article in Developmental neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- Two-Step Actions of Testicular Androgens in the Organization of a Male-Specific Neural Pathway from the Medial Preoptic Area to the Ventral Tegmental Area for Modulating Sexually Motivated Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Contribution of birds to the study of sexual differentiation of brain and behavior.Hormones and behavior · 2023Article
- The effects of early life stress on motivated behaviors: A role for gonadal hormones.Neuroscience and biobehavioral reviews · 2020Review
- Sex differences in dendritic spine density and morphology in auditory and visual cortices in adolescence and adulthood.Scientific reports · 2020Article
- The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity.International journal of molecular sciences · 2020Article
- Neuroendocrine-Immune Crosstalk Shapes Sex-Specific Brain Development.Endocrinology · 2020Review
- A new view of sexual differentiation of mammalian brain.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Sexually Dimorphic Formation of the Preoptic Area and the Bed Nucleus of the Stria Terminalis by Neuroestrogens.Frontiers in neuroscience · 2020Review
- Lost in translational biology: Understanding sex differences to inform studies of diseases of the nervous system.Brain research · 2019Review
- Prenatal Allergen Exposure Perturbs Sexual Differentiation and Programs Lifelong Changes in Adult Social and Sexual Behavior.Scientific reports · 2019Article
- Is Sexual Differentiation of Brain and Behavior Epigenetic?Current opinion in behavioral sciences · 2019Article
- Microglia: Driving critical periods and sexual differentiation of the brain.Developmental neurobiology · 2018Review
- Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.Cell reports · 2018Article
- Fast, furious and enduring: Sensitive versus critical periods in sexual differentiation of the brain.Physiology & behavior · 2018Review
- Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function.Frontiers in immunology · 2018Review
- Revisiting medial preoptic area plasticity induced in male mice by sexual experience.Scientific reports · 2017Article
- Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain.Nature reviews. Neuroscience · 2017Review
- Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder.Biological psychiatry · 2017Review
- Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.Frontiers in neuroendocrinology · 2016Review
- Surprising origins of sex differences in the brain.Hormones and behavior · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Prostaglandin E2 (PGE2) mediates the organization of male rat sexual behavior and medial preoptic area (MPOA) neuroanatomy during a sensitive perinatal window. PGE2 is up-regulated in response to estradiol, and initiates a two-fold increase in dendritic spines densities on neurons. All the four receptors for PGE2 and EP1-4 are present in developing POA, a critical region controlling male sexual behavior. Previous studies explored that EP receptors are involved in PGE2-induction of neonatal levels of spinophilin protein, a surrogate marker for dendritic spine formation, but did not assess behavioral masculinization. Here, we used two approaches, suppression of EP receptor expression with antisense oligonucleotides and activation of EP receptors with selective agonists, to test which receptors are necessary and sufficient, respectively, for the effects of PGE2 on behavior and neuronal morphology. In female rats, neonatal treatment with antisense oligonucleotides against EP2 or EP4 but not EP1 or EP3 completely prevented the expression of adult behavior organized by PGE2 exposure. The effects of ONO-DI-004, ONO-AE-259-01, ONO-AE-248, and ONO-AE1-329 (EP1-4 agonists respectively) were equivalent to PGE2 treatment, which suggests activating any EP receptor neonatally suffices in masculinizing sex behavior. When given alone, not all EP agonists increased neonatal POA spinophilin levels; yet giving each agonist neonatally increased adult levels. Moreover, adult spinophilin levels significantly correlated with two measures of male sexual behavior. The body of evidence suggests that EP2 and EP4 are both necessary and sufficient for PGE2-induced masculinization of sex behavior, whereas EP1 and EP3 provide redundant roles.
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