ArticleCurrent genetics2008
Involvement of putative response regulator genes of the rice blast fungus Magnaporthe oryzae in osmotic stress response, fungicide action, and pathogenicity.
Article in Current genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 91 citations in OpenAlex.
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- Research on the Molecular Interaction Mechanism between Plants and Pathogenic Fungi.International journal of molecular sciences · 2022Review
- Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae.Journal of industrial microbiology & biotechnology · 2021Review
- A Radical Reimagining of Fungal Two-Component Regulatory Systems.Trends in microbiology · 2021Review
- Distinct role of HAMP and HAMP-like linker domains in regulating the activity of Hik1p, a hybrid histidine kinase 3 from Magnaporthe oryzae.Molecular genetics and genomics : MGG · 2021Article
- Regulation of biotic interactions and responses to abiotic stresses by MAP kinase pathways in plant pathogenic fungi.Stress biology · 2021Review
- Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically RegulateJournal of fungi (Basel, Switzerland) · 2021Article
- STK-12 acts as a transcriptional brake to control the expression of cellulase-encoding genes in Neurospora crassa.PLoS genetics · 2019Article
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- Acetylation of BcHpt Lysine 161 RegulatesFrontiers in microbiology · 2019Article
- Involvement of a Response Regulator VdSsk1 in Stress Response, Melanin Biosynthesis and Full Virulence inFrontiers in microbiology · 2019Article
- Functional characterization of the upstream components of the Hog1-like kinase cascade in hyperosmotic and carbon sensing inBiotechnology for biofuels · 2018Article
- Roles of Three HSF Domain-Containing Proteins in Mediating Heat-Shock Protein Genes and Sustaining Asexual Cycle, Stress Tolerance, and Virulence inFrontiers in microbiology · 2018Article
- The Interactomic Analysis Reveals Pathogenic Protein Networks inFrontiers in genetics · 2018Article
- Phosphorylation-mediated Regulatory Networks in Mycelia ofMolecular & cellular proteomics : MCP · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rice blast fungus (Magnaporthe oryzae) has ten histidine kinases (HKs), one histidine-containing phosphotransfer protein (HPt), and three response regulators (RRs) as putative components of the two-component signal transduction system (TCS). Here, we constructed knockout mutants of two putative RR genes (MoSSK1, MoSKN7) and a RR homolog gene (MoRIM15) to analyze the roles of TCS in environmental adaptation and pathogenicity. The DeltaMossk1 strain had increased sensitivity to high osmolarity and decreased sensitivity to fludioxonil. The DeltaMoskn7 strain had slightly decreased sensitivity to fludioxonil. The involvement of MoSkn7 in the osmoresponse was obvious only on the DeltaMossk1 background. These results show that MoSsk1 and MoSkn7 are major and minor contributors, respectively, in the high osmolarity response and fludioxonil action. The DeltaMossk1 strain was more osmosensitive than the predicted upstream HK gene disruptant Deltahik1, which shows sugar-specific high osmolarity sensitivity. The DeltaMossk1 and DeltaMoskn7 strains showed enhanced hyphal melanization, suggesting that RRs regulate hyphal melanization. MoSsk1 and MoRim15 are required for full virulence, because the DeltaMossk1 and DeltaMorim15 strains exhibited reduced virulence. These results suggest that the putative RRs of the rice blast fungus are involved in the osmotic stress response, fludioxonil action, and pathogenicity.
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