ArticleJournal of the American Academy of Child and Adolescent Psychiatry2008
Global and temporal cortical folding in patients with early-onset schizophrenia.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 45 citations in OpenAlex.
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations.AIMS neuroscience · 2024Article
- Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability.Brain structure & function · 2023Article
- Towards Deciphering the Fetal Foundation of Normal Cognition and Cognitive Symptoms From Sulcation of the Cortex.Frontiers in neuroanatomy · 2021Article
- The reliability and heritability of cortical folds and their genetic correlations across hemispheres.Communications biology · 2020Article
- Three-Dimensional Probabilistic Maps of Mesial Temporal Lobe Structures in Children and Adolescents' Brains.Frontiers in neuroanatomy · 2018Article
- Deviations in cortex sulcation associated with visual hallucinations in schizophrenia.Molecular psychiatry · 2015Article
- Local gyrification index in probands with psychotic disorders and their first-degree relatives.Biological psychiatry · 2014Article
- Atypical sulcal anatomy in young children with autism spectrum disorder.NeuroImage. Clinical · 2014Article
- Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings.Child and adolescent psychiatric clinics of North America · 2013Review
- Cortex morphology in first-episode psychosis patients with neurological soft signs.Schizophrenia bulletin · 2013Article
- Article
- Consistency and interpretation of changes in millimeter-scale cortical intrinsic curvature across three independent datasets in schizophrenia.NeuroImage · 2012Article
- "Where do auditory hallucinations come from?"--a brain morphometry study of schizophrenia patients with inner or outer space hallucinations.Schizophrenia bulletin · 2011Article
- Cortical folding in patients with bipolar disorder or unipolar depression.Journal of psychiatry & neuroscience : JPN · 2009Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAdult-onset schizophrenia has repeatedly been associated with disturbances in the temporal lobes and alterations in cortical folding, which are thought to reflect neurodevelopmental impairment. Early-onset schizophrenia (EOS; onset before 18 years) is considered to involve even more pronounced neurodevelopmental deviance across a wide range of brain structural measures. We hypothesized that overall alteration of cortical folding also applies to EOS, and EOS involves prominent structural aberrations in superior temporal and collateral sulci.
methodMagnetic resonance T1 images of 51 patients with EOS and 59 healthy participants were investigated. A fully automated method was applied to the images to extract, label, and measure the sulcus area in the whole cortex. Cortical folding was assessed by computing global sulcal indices (the ratio between total sulcal area and total outer cortex area) for each hemisphere and local sulcal indices (the ratio between the area of labeled sulcus and total outer cortex area in the corresponding hemisphere) for superior temporal and collateral sulci.
resultsRelative to healthy individuals, patients with EOS had significantly lower global sulcal indices in both hemispheres and a lower local sulcal index in the left collateral sulcus.
conclusionsReduced hemispheric sulcation appears to be a feature of schizophrenia, irrespective of age at onset. Structural aberration involving the left collateral sulcus may contribute to neurobiological substrate of EOS.
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