ArticleInternational journal of STD & AIDS2008
Independent clinical predictors of impaired response to hepatitis B vaccination in HIV-infected persons.
Article in International journal of STD & AIDS, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Hepatitis B Vaccination Induced TNF-Journal of immunology research · 2018Trial
- Hepatitis B vaccination in HIV-infected youth: a randomized trial of three regimens.Journal of acquired immune deficiency syndromes (1999) · 2011Trial
- Hepatitis B Vaccination Rates and Risk Factors Affecting Vaccine Response in People Living with HIV in Turkey.Current HIV research · 2026Observational
- Chronic hepatitis B and HIV coinfection.Topics in antiviral medicine · 2023Review
- Prevalence and the associated factors of hepatitis B and hepatitis C viral infections among HIV-positive individuals in same-day antiretroviral therapy initiation program in Bangkok, Thailand.BMC public health · 2022Article
- HIV and the liver.Topics in antiviral medicine · 2019Article
- HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model.BMC medicine · 2019Article
- Hepatitis B virus vaccination in HIV-infected people: A review.Human vaccines & immunotherapeutics · 2017Review
- Response to hepatitis B vaccination among HIV-infected adults in Vietnam.Journal of virus eradication · 2016Article
- Unsolved problems and future perspectives of hepatitis B virus vaccination.World journal of gastroenterology · 2015Review
- Prevention of hepatitis B virus infection: from the past to the future.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
- Hepatitis B and A vaccination in HIV-infected adults: A review.Human vaccines & immunotherapeutics · 2015Review
- Hepatitis B virus coinfection in human immunodeficiency virus-infected patients: a review.World journal of gastroenterology · 2014Review
- Hepatitis B vaccine by intradermal route in non responder patients: an update.World journal of gastroenterology · 2014Review
- Serological response to one intradermal or intramuscular hepatitis B virus vaccine booster dose in human immunodeficiency virus-infected nonresponders to standard vaccination.Perspectives in clinical research · 2014Article
- Rapid loss of vaccine-acquired hepatitis B surface antibody after three doses of hepatitis B vaccination in HIV-infected persons.International journal of STD & AIDS · 2014Article
- Immune response to hepatitis B virus vaccination among HIV-1 infected and uninfected adults in Kenya.The Journal of infectious diseases · 2013Article
- Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1.The Lancet. Infectious diseases · 2012Review
- The impact of alcohol on BCG-induced immunity against Mycobacterium tuberculosis.Alcoholism, clinical and experimental research · 2012Article
- Persistence of Protective Hepatitis B Surface Antibody Titers after Successful Double-Dose Hepatitis B Virus Rescue Vaccination in HIV-Infected Patients.Gut and liver · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Protective response rates to hepatitis B (HB) vaccination have been reported as low as 18-62% in HIV-infected persons. The relative importance of various predictors for this poor response has not been fully characterized. In this retrospective cohort study, we examined the relationship between clinical characteristics and vaccine non-response (HB surface antibody <10 IU/L) among patients attending an urban HIV clinic. Among the 97 patients who met the inclusion criteria, 43 (44%) developed a protective antibody response. In multivariate analyses, age >40 years (odds ratio [OR] 3.03 [95% confidence interval [CI], 1.14-8.06]; P = 0.026) and alcohol abuse (OR 4.92 [95% CI, 1.72-20.89]; P = 0.007) were independent predictors of failure to develop vaccine response. In addition, CD4 nadir <200 (OR 7.24 [95% CI, 1.91-27.41]; P = 0.004), rather than CD4 current to vaccination, remained a strong independent risk factor. Patients with HIV viral suppression on highly active antiretroviral therapy had a significantly lower rate of vaccine failure (OR 0.31 [95% CI, 0.11-0.91]; P = 0.033), after adjusting for these other covariates. Our findings underscore the importance of confirming seroconversion after HB vaccination in HIV-infected patients and initiating vaccination early in the course of HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.