ArticleAntimicrobial agents and chemotherapy2008
A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 77 citations in OpenAlex.
- Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering.Angewandte Chemie (International ed. in English) · 2023Article
- Dynamic state of plasmid genomic architectures resulting from XerC/D-mediated site-specific recombination inFrontiers in microbiology · 2023Article
- Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2022Article
- Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture.Antimicrobial resistance and infection control · 2021Review
- The effect of an antibiotic stewardship program on tigecycline use in a Tertiary Care Hospital, an intervention study.Annals of clinical microbiology and antimicrobials · 2020Article
- The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria.Antibiotics (Basel, Switzerland) · 2020Review
- Investigation of multidrug-resistant ST2 Acinetobacter baumannii isolated from Saint George hospital in Lebanon.BMC microbiology · 2019Article
- Article
- Review
- Site-Specific Recombination at XerC/D Sites Mediates the Formation and Resolution of Plasmid Co-integrates Carrying aFrontiers in microbiology · 2018Article
- TheAntimicrobial agents and chemotherapy · 2017Article
- Article
- Resistance to Macrolide Antibiotics in Public Health Pathogens.Cold Spring Harbor perspectives in medicine · 2016Review
- Effects of Saline, an Ambient Acidic Environment, and Sodium Salicylate on OXA-Mediated Carbapenem Resistance in Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2016Article
- The Genetic Analysis of an Acinetobacter johnsonii Clinical Strain Evidenced the Presence of Horizontal Genetic Transfer.PloS one · 2016Article
- Article
- Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.Iranian journal of microbiology · 2015Review
- Investigation of the molecular epidemiology of Acinetobacter baumannii isolated from patients and environmental contamination.The Journal of antibiotics · 2015Article
- Molecular epidemiology of Acinetobacter baumannii in different hospitals in Tripoli, Lebanon using bla(OXA-51-like) sequence based typing.BMC microbiology · 2015Article
- Extrahuman epidemiology of Acinetobacter baumannii in Lebanon.Applied and environmental microbiology · 2015Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the basis of the carbapenem resistance of 17 multidrug-resistant Acinetobacter baumannii clinical isolates collected from 2004 to 2005 at the Saint George University Hospital in Beirut, Lebanon. A. baumannii isolates were clonally related and were susceptible to colistin and trimethoprim-sulfamethoxazole, susceptible or intermediate to ampicillin-sulbactam and meropenem, and resistant to all other antimicrobials. Conjugation experiments demonstrated that resistance to imipenem could be transferred along with a plasmid containing the carbapenem-hydrolyzing oxacillinase bla(OXA-58) gene. The plasmid that we called pABIR was 29,823 bp in size and showed a novel mosaic structure composed of two origins of replication, four insertion sequence (IS) elements, and 28 open reading frames. The bla(OXA-58) gene was flanked by IS18 and ISAba3 elements at the 5' and 3' ends, respectively. The production of the carbapenem-hydrolyzing oxacillinase OXA-58 was apparently the only mechanism for carbapenem resistance in A. baumannii isolates causing the outbreak at the Lebanese Hospital.
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