ArticleMicrobes and infection2008
Dendritic cells from C57BL/6 mice undergo activation and induce Th1-effector cell responses against Campylobacter jejuni.
Article in Microbes and infection, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Th1/Th17-mediated Immunity and Protection from Peripheral Neuropathy in Wildtype and IL10Comparative medicine · 2022Article
- Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter.Scientific reports · 2021Article
- Host-specific differences in the response of cultured macrophages to Campylobacter jejuni capsule and O-methyl phosphoramidate mutants.Veterinary research · 2018Article
- Campylobacter jejuni and associated immune mechanisms: short-term effects and long-term implications for infants in low-income countries.Current opinion in infectious diseases · 2017Review
- Virulence genes and cytokine profile in systemic murine Campylobacter coli infection.Virulence · 2015Article
- Inflammasome activation by Campylobacter jejuni.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Peripheral CD4+ T cell cytokine responses following human challenge and re-challenge with Campylobacter jejuni.PloS one · 2014Article
- The Campylobacter jejuni CiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease.Cell communication and signaling : CCS · 2013Article
- Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells.Infection and immunity · 2012Article
- Campylobacter jejuni induces extra-intestinal immune responses via Toll-like-receptor-4 signaling in conventional IL-10 deficient mice with chronic colitis.European journal of microbiology & immunology · 2012Article
- TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.Cell · 2012Article
- The Campylobacter jejuni NCTC11168 capsule prevents excessive cytokine production by dendritic cells.Medical microbiology and immunology · 2012Article
- Campylobacter jejuni induces acute enterocolitis in gnotobiotic IL-10-/- mice via Toll-like-receptor-2 and -4 signaling.PloS one · 2012Article
- Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner.Infection and immunity · 2011Article
- Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.Nature immunology · 2010Article
- Assessment of the duration of protection in Campylobacter jejuni experimental infection in humans.Infection and immunity · 2010Article
- Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Food-borne Campylobacter jejuni (Cj) is an important cause of enteritis. We showed that C57BL/6 and congenic interleukin (IL)-10(-/-) mice serve as models of Cj colonization and enteritis, respectively. Thus, C57BL/6 mice are resistant to Cj induced disease. Because dendritic cells (DCs) are central to regulating adaptive immune responses, we investigated the interaction of Cj with murine bone marrow-derived DCs (BM-DCs) to assess bacterial killing, DC activation, and the ability of Cj-infected BM-DCs to stimulate Campylobacter-specific T cell responses in vitro. BM-DCs challenged with Cj efficiently internalized and killed Cj 11168 and significantly upregulated surface MHC-II, CD40, CD80 and CD86 demonstrating a mature phenotype. Infected BM-DCs secreted significant amounts of tumor necrosis factor-alpha (TNF-alpha), IL-6 and IL-12p70. Formalin-killed Cj also induced maturation of BM-DCs with similar cytokine production but at a significantly lower magnitude than live bacteria. Maximal activation of murine BM-DCs required internalization of Cj; attachment alone was not sufficient to elicit significant responses. Also, various strains of Cj elicited different magnitudes of cytokine production from BM-DCs. Finally, in a coculture system, Cj-infected BM-DCs induced high level interferon-gamma (INF-gamma) production from CD4+T cells indicating Th1 polarization. Thus, DCs from resistant C57BL/6 mice initiate T cell responses against Cj.
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Registered trials
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