ArticleNeurochemistry international2008
Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery.
Article in Neurochemistry international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
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- Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury.American journal of physiology. Cell physiology · 2018Article
- Application of wavelet analysis to detect dysfunction in cerebral blood flow autoregulation during experimental hyperhomocysteinaemia.Lasers in medical science · 2018Article
- Role of Homocysteine in Cognitive Impairement and Alzheimer's Disease.Indian journal of clinical biochemistry : IJCB · 2018Review
- Vascular Remodeling, Oxidative Stress, and Disrupted PPARPPAR research · 2018Article
- "Boomerang Neuropathology" of Late-Onset Alzheimer's Disease is Shrouded in Harmful "BDDS": Breathing, Diet, Drinking, and Sleep During Aging.Neurotoxicity research · 2015Review
- Effect of homocysteine on intestinal permeability in rats with experimental colitis, and its mechanism.Gastroenterology report · 2014Article
- Hyperhomocysteinemia promotes vascular remodeling in vein graph in mice.Frontiers in bioscience (Landmark edition) · 2014Article
- Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid.Journal of molecular neuroscience : MN · 2014Article
- Plasma homocysteine is associated with aortic arterial stiffness but not wave reflection in Chinese hypertensive subjects.PloS one · 2014Article
- Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.International journal of physiology, pathophysiology and pharmacology · 2013Article
- Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor.Molecular and cellular biochemistry · 2012Article
- Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia.Journal of molecular neuroscience : MN · 2012Article
- Folic acid improves inner ear vascularization in hyperhomocysteinemic mice.Hearing research · 2012Article
- Autophagy mechanism of right ventricular remodeling in murine model of pulmonary artery constriction.American journal of physiology. Heart and circulatory physiology · 2012Article
- X-ray imaging of differential vascular density in MMP-9-/-, PAR-1-/+, hyperhomocysteinemic (CBS-/+) and diabetic (Ins2-/+) mice.Archives of physiology and biochemistry · 2011Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
An elevated level of Homocysteine (Hcy) is a risk factor for vascular dementia and stroke. Cysthathionine beta Synthase (CBS) gene is involved in the clearance of Hcy. Homozygous individuals for (CBS-/-) die early, but heterozygous for (CBS-/+) survive with high levels of Hcy. The gamma-Amino Butyric Acid (GABA) presents in the central nervous system (CNS) and functions as an inhibitory neurotransmitter. Hcy competes with GABA at the GABA(A) receptor and affects the CNS function. We hypothesize that Hcy causes a decrease in blood flow to the brain due to increase in vascular resistance (VR) because of arterial remodeling in the carotid artery (CA). Blood pressure and blood flow in CA of wild type (WT), CBS-/+, CBS-/+ GABA(A)-/- double knockout, and GABA(A)-/- were measured. CA was stained with trichrome, and the brain permeability was measured. Matrix Metalloproteinases (MMP-2 and MMP-9), tissue inhibitor of metalloproteinase (TIMP-3, TIMP-4), elastin, and collagen-III expression were measured by real-time polymerase chain reaction (RT-PCR). Results showed an increase in VR in CBS-/+/GABA(A)-/-double knockout>CBS-/+/>GABA(A)-/- compared to WT mice. Increased MMP-2, MMP-9, collagen-III and TIMP-3 mRNA levels were found in GABA(A)-/-, CBS-/+, CBS-/+/GABA(A) double knockout compared to WT. The levels of TIMP-4 and elastin were decreased, whereas the levels of MMP-2, MMP-9 and TIMP-3 increased, which indirectly reflected the arterial resistance. These results suggested that Hcy caused arterial remodeling in part, by increase in collagen/elastin ratio thereby increasing VR leading to the decrease in CA blood flow.
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