ArticleBiochemical and biophysical research communications2008
VIP induces PKA-mediated rapid and sustained phosphorylation of HSP20.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Inhibitory Effect ofDrug design, development and therapy · 2021Article
- Reversing Acute Kidney Injury Using Pulsed Focused Ultrasound and MSC Therapy: A Role for HSP-Mediated PI3K/AKT Signaling.Molecular therapy. Methods & clinical development · 2020Article
- Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure.Journal of molecular and cellular cardiology · 2011Review
- Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Bioengineered three-dimensional physiological model of colonic longitudinal smooth muscle in vitro.Tissue engineering. Part C, Methods · 2010Article
- Successful implantation of physiologically functional bioengineered mouse internal anal sphincter.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- The small heat shock protein, HSPB6, in muscle function and disease.Cell stress & chaperones · 2010Review
- Role of thin-filament regulatory proteins in relaxation of colonic smooth muscle contraction.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The small molecular weight heat shock protein HSP20 has been proposed to regulate smooth muscle relaxation in a manner dependent on its phosphorylated state. We present the first evidence of HSP20 phosphorylation in response to a naturally occurring neurotransmitter. HSP20 was rapidly phosphorylated in colonic circular smooth muscle cells exposed to the physiologically relevant relaxant neuropeptide, Vasoactive Intestinal Peptide (VIP). HSP20 phosphorylation was significantly and substantially increased by 30s following VIP treatment and remained elevated for 30 min. VIP-induced HSP20 phosphorylation was dose dependent. Both basal and VIP-induced HSP20 phosphorylations were solely mediated by Protein Kinase A. Maximal phosphorylation of HSP20 was induced by the same VIP concentration range which induces maximal relaxation. Increased phosphorylation of HSP20 occurred in both cytosolic and particulate cell fractions. Our findings represent evidence for neurogenic modulation of the cyclic molecular regulation of relaxation required for peristalsis via a VIP-PKA-HSP20 pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.