ArticleJournal of the American Academy of Child and Adolescent Psychiatry2008
CBCL pediatric bipolar disorder profile and ADHD: comorbidity and quantitative trait loci analysis.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Dysregulation in Youth with Anxiety Disorders: Relationship to Acute and 7- to 19- Year Follow-Up Outcomes of Cognitive-Behavioral Therapy.Child psychiatry and human development · 2016Trial
- Further Evidence of an Association Between a Positive Child Behavior Checklist-Bipolar Profile and a Diagnosis of Pediatric Bipolar Disorder: A Meta-Analysis.Scandinavian journal of child and adolescent psychiatry and psychology · 2023Article
- The role of genetic and environmental factors in covariation between anxiety and anger in childhood.European child & adolescent psychiatry · 2021Article
- Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation.Translational psychiatry · 2019Article
- Evaluation of the Strengths and Difficulties Questionnaire-Dysregulation Profile (SDQ-DP).Psychological assessment · 2018Article
- Loss of Temper and Irritability: The Relationship to Tantrums in a Community and Clinical Sample.Journal of child and adolescent psychopharmacology · 2016Article
- Further evidence that severe scores in the aggression/anxiety-depression/attention subscales of child behavior checklist (severe dysregulation profile) can screen for bipolar disorder symptomatology: a conditional probability analysis.Journal of affective disorders · 2014Article
- A potential electroencephalography and cognitive biosignature for the child behavior checklist-dysregulation profile.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Article
- Personal and familial correlates of bipolar (BP)-I disorder in children with a diagnosis of BP-I disorder with a positive child behavior checklist (CBCL)-severe dysregulation profile: a controlled study.Journal of affective disorders · 2013Article
- Correlates of the CBCL-dysregulation profile in preschool-aged children.Journal of child psychology and psychiatry, and allied disciplines · 2012Article
- Temperamental profiles of dysregulated children.Child psychiatry and human development · 2012Article
- Severity of the aggression/anxiety-depression/attention child behavior checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention-deficit hyperactivity disorder.Journal of developmental and behavioral pediatrics : JDBP · 2012Article
- A magnetic resonance spectroscopy study of the anterior cingulate cortex in youth with emotional dysregulation.The Israel journal of psychiatry and related sciences · 2012Article
- Genome-wide association study of the child behavior checklist dysregulation profile.Journal of the American Academy of Child and Adolescent Psychiatry · 2011Article
- Using linkage information to weight a genome-wide association of bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder.The British journal of psychiatry : the journal of mental science · 2011Article
- Child Behavior Checklist Scores for School-Aged Children with Autism: Preliminary Evidence of Patterns Suggesting the Need for Referral.Journal of psychopathology and behavioral assessment · 2011Article
- Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths.The American journal of psychiatry · 2011Article
- Adult outcomes of childhood dysregulation: a 14-year follow-up study.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Article
- Cross-informant agreement of the Dysregulation Profile of the Child Behavior Checklist.Psychiatry research · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe pediatric bipolar disorder profile of the Child Behavior Checklist (CBCL-PBD), a parent-completed measure that avoids clinician ideological bias, has proven useful in differentiating patients with attention-deficit/hyperactivity disorder (ADHD). We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a sample of multiple affected ADHD sibling pairs.
methodA total of 540 ADHD subjects ages 5 to 18 years were assessed with the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version and CBCL. Parents were assessed with the Schedule for Affective Disorders and Schizophrenia-Lifetime version supplemented by the Schedule for Affective Disorders and Schizophrenia for School-Age Children for disruptive behavioral disorders. Patterns of psychiatric comorbidity were contrasted based on the CBCL-PBD profile. A quantitative trait loci variance component analysis was used to identify potential genomic regions that may harbor susceptibility genes for the CBCL-PBD quantitative phenotype.
resultsBipolar spectrum disorders represented less than 2% of the overall sample. The CBCL-PBD classification was associated with increased generalized anxiety disorder (p =.001), oppositional defiant disorder (p =.008), conduct disorder (p =.003), and parental substance abuse (p =.005). A moderately significant linkage signal (multipoint maximum lod score = 2.5) was found on chromosome 2q.
conclusionsThe CBCL-PBD profile distinguishes a subset of ADHD patients with significant comorbidity. Linkage analysis of the CBCL-PBD phenotype suggests certain genomic regions that merit further investigation for genes predisposing to severe psychopathology.
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