Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2008
Remission status and cortical thickness in childhood-onset schizophrenia.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Impact cérébral structurel et fonctionnel de la Clozapine chez les patients souffrant de schizophrénie : revue systématique des études longitudinales en neuroimagerie.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Article
- Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors.Human brain mapping · 2020Article
- Predictors of outcome in early-onset psychosis: a systematic review.NPJ schizophrenia · 2015Review
- A comparison of neuroimaging findings in childhood onset schizophrenia and autism spectrum disorder: a review of the literature.Frontiers in psychiatry · 2013Review
- A family affair: brain abnormalities in siblings of patients with schizophrenia.Brain : a journal of neurology · 2013Review
- Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis.Expert review of neurotherapeutics · 2013Review
- Neuroimaging schizophrenia: a picture is worth a thousand words, but is it saying anything important?Current psychiatry reports · 2013Review
- The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012Review
- Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophrenia.Schizophrenia research · 2010Article
- General absence of abnormal cortical asymmetry in childhood-onset schizophrenia: a longitudinal study.Schizophrenia research · 2009Article
- Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveFew studies have examined prediction of schizophrenia outcome in relation to brain magnetic resonance imaging measures. In this study, remission status at the time of discharge was examined in relation to admission cortical thickness for childhood-onset schizophrenia probands. We hypothesized that total, frontal, temporal, and parietal gray matter thickness would be greater in patients who subsequently remit.
methodThe relation between admission cortical brain thickness on magnetic resonance imaging and remission status at the time of discharge an average of 3 months later was examined for 56 individuals (32 males) ages 6 to 19 diagnosed with childhood-onset schizophrenia. Cortical thickness was measured across the cerebral hemispheres at admission. Discharge remission criteria were adapted from the 2005 Remission in Schizophrenia Working Group criteria.
resultsPatients remitted at discharge (n = 16 [29%]) had thicker regional cortex in left orbitofrontal, left superior, and middle temporal gyri and bilateral postcentral and angular gyri (p < or = .008).
conclusionsOur results provide neuroanatomic correlates of clinical remission in schizophrenia and evidence that response to treatment may be mediated by these cortical brain regions.
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