ArticleGenetics2008
The rate and character of spontaneous mutation in Thermus thermophilus.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genomic traits associated with copiotrophy decouple from maximum growth rate predictions along temperature gradients.The ISME journal · 2026Article
- Genomic attributes of thermophilic and hyperthermophilic bacteria and archaea.World journal of microbiology & biotechnology · 2022Review
- Unexpectedly high mutation rate of a deep-sea hyperthermophilic anaerobic archaeon.The ISME journal · 2021Article
- Article
- Development of a supF-based mutation-detection system in the extreme thermophile Thermus thermophilus HB27.Molecular genetics and genomics : MGG · 2019Article
- The apt/6-Methylpurine Counterselection System and Its Applications in Genetic Studies of the Hyperthermophilic Archaeon Sulfolobus islandicus.Applied and environmental microbiology · 2016Article
- Adaptive engineering of a hyperthermophilic archaeon on CO and discovering the underlying mechanism by multi-omics analysis.Scientific reports · 2016Article
- A mutant ('lab strain') of the hyperthermophilic archaeon Pyrococcus furiosus, lacking flagella, has unusual growth physiology.Extremophiles : life under extreme conditions · 2015Article
- Confounders of mutation-rate estimators: selection and phenotypic lag in Thermus thermophilus.Mutation research · 2013Review
- Growth temperature and genome size in bacteria are negatively correlated, suggesting genomic streamlining during thermal adaptation.Genome biology and evolution · 2013Article
- Article
- Proteome analyses of hydrogen-producing hyperthermophilic archaeon Thermococcus onnurineus NA1 in different one-carbon substrate culture conditions.Molecular & cellular proteomics : MCP · 2012Article
- Measurements of spontaneous rates of mutations in the recent past and the near future.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- MutS and MutL are dispensable for maintenance of the genomic mutation rate in the halophilic archaeon Halobacterium salinarum NRC-1.PloS one · 2010Article
- Avoiding dangerous missense: thermophiles display especially low mutation rates.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Selection of spontaneous, loss-of-function mutations at two chromosomal loci (pyrF and pyrE) enabled the first molecular-level analysis of replication fidelity in the extremely thermophilic bacterium Thermus thermophilus. Two different methods yielded similar mutation rates, and mutational spectra determined by sequencing of independent mutants revealed a variety of replication errors distributed throughout the target genes. The genomic mutation rate estimated from these targets, 0.00097 +/- 0.00052 per replication, was lower than corresponding estimates from mesophilic microorganisms, primarily because of a low rate of base substitution. However, both the rate and spectrum of spontaneous mutations in T. thermophilus resembled those of the thermoacidophilic archaeon Sulfolobus acidocaldarius, despite important molecular differences between these two thermophiles and their genomes.
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