ArticleGenetics2008
Rtf1-mediated eukaryotic site-specific replication termination.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning.Epigenetics & chromatin · 2019Article
- Loss of Cohesin Subunit Rec8 Switches Rad51 Mediator Dependence in Resistance to Formaldehyde Toxicity inGenetics · 2018Article
- Review
- Timeless protection of telomeres.Current genetics · 2016Review
- Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Polymerase δ replicates both strands after homologous recombination-dependent fork restart.Nature structural & molecular biology · 2015Article
- Article
- The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.PloS one · 2015Article
- The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.Journal of cell science · 2014Article
- Establishment of a replication fork barrier following induction of DNA binding in mammalian cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Impediments to replication fork movement: stabilisation, reactivation and genome instability.Chromosoma · 2013Review
- Article
- The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast.PLoS genetics · 2013Article
- Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast.Cell reports · 2012Article
- Local and global functions of Timeless and Tipin in replication fork protection.Cell cycle (Georgetown, Tex.) · 2012Review
- Timeless preserves telomere length by promoting efficient DNA replication through human telomeres.Cell cycle (Georgetown, Tex.) · 2012Article
- The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability.Genes & development · 2012Article
- Recovery of arrested replication forks by homologous recombination is error-prone.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The molecular mechanisms mediating eukaryotic replication termination and pausing remain largely unknown. Here we present the molecular characterization of Rtf1 that mediates site-specific replication termination at the polar Schizosaccharomyces pombe barrier RTS1. We show that Rtf1 possesses two chimeric myb/SANT domains: one is able to interact with the repeated motifs encoded by the RTS1 element as well as the elements enhancer region, while the other shows only a weak DNA binding activity. In addition we show that the C-terminal tail of Rtf1 mediates self-interaction, and deletion of this tail has a dominant phenotype. Finally, we identify a point mutation in Rtf1 domain I that converts the RTS1 element into a replication barrier of the opposite polarity. Together our data establish that multiple protein DNA and protein-protein interactions between Rtf1 molecules and both the repeated motifs and the enhancer region of RTS1 are required for site-specific termination at the RTS1 element.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.