ArticleGenetics2008
Sex-biased lethality or transmission of defective transcription machinery in Arabidopsis.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Co-transcriptional splicing changes combine with reduced productive transcription initiation for cold-induced repression of FLC.Nucleic acids research · 2026Article
- Article
- The nuclear exosome subunit HEN2 acts independently of the core exosome to assist transcription in Arabidopsis.Plant physiology · 2024Article
- Transcriptional Profiling Reveals the Wheat Defences against Fusarium Head Blight Disease Regulated by a NAC Transcription Factor.Plants (Basel, Switzerland) · 2023Article
- Article
- R-loops at microRNA encoding loci promote co-transcriptional processing of pri-miRNAs in plants.Nature plants · 2022Article
- Intragenic tRNA-promoted R-loops orchestrate transcription interference for plant oxidative stress responses.The Plant cell · 2021Article
- Phenotypic Characteristics and Transcriptome of Cucumber Male Flower Development Under Heat Stress.Frontiers in plant science · 2021Article
- Loss of Function of an RNA Polymerase III Subunit Leads to Impaired Maize Kernel Development.Plant physiology · 2020Article
- Organismal benefits of transcription speed control at gene boundaries.EMBO reports · 2020Article
- Article
- Native elongation transcript sequencing reveals temperature dependent dynamics of nascent RNAPII transcription in Arabidopsis.Nucleic acids research · 2020Article
- Arabidopsis JANUS Regulates Embryonic Pattern Formation through Pol II-Mediated Transcription of WOX2 and PIN7.iScience · 2019Article
- The Pol IV largest subunit CTD quantitatively affects siRNA levels guiding RNA-directed DNA methylation.Nucleic acids research · 2019Article
- Article
- Transcriptional read-through of the long non-coding RNA SVALKA governs plant cold acclimation.Nature communications · 2018Article
- Duplication and Loss of Function of Genes Encoding RNA Polymerase III Subunit C4 Causes Hybrid Incompatibility in Rice.G3 (Bethesda, Md.) · 2017Article
- NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.Development (Cambridge, England) · 2016Article
- A partial loss-of-function mutation in an Arabidopsis RNA polymerase III subunit leads to pleiotropic defects.Journal of experimental botany · 2016Article
- Evolution of haploid selection in predominantly diploid organisms.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Unlike animals, whose gametes are direct products of meiosis, plant meiotic products undergo additional rounds of mitosis, developing into multicellular haploid gametophytes that produce egg or sperm cells. The complex development of gametophytes requires extensive expression of the genome, with DNA-dependent RNA polymerases I, II, and III being the key enzymes for nuclear gene expression. We show that loss-of-function mutations in genes encoding key subunits of RNA polymerases I, II, or III are not transmitted maternally due to the failure of female megaspores to complete the three rounds of mitosis required for the development of mature gametophytes. However, male microspores bearing defective polymerase alleles develop into mature gametophytes (pollen) that germinate, grow pollen tubes, fertilize wild-type female gametophytes, and transmit the mutant genes to the next generation at moderate frequency. These results indicate that female gametophytes are autonomous with regard to gene expression, relying on transcription machinery encoded by their haploid nuclei. By contrast, male gametophytes make extensive use of transcription machinery that is synthesized by the diploid parent plant (sporophyte) and persists in mature pollen. As a result, the expected stringent selection against nonfunctional essential genes in the haploid state occurs in the female lineage but is relaxed in the male lineage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.