ArticleGenetics2008
Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex.Nature communications · 2025Article
- Developmental changes in nuclear lamina components during germ cell differentiation.Nucleus (Austin, Tex.) · 2024Article
- Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila.PLoS biology · 2024Article
- Analysis of a rare progeria variant of Barrier-to-autointegration factor in Drosophila connects centromere function to tissue homeostasis.Cellular and molecular life sciences : CMLS · 2023Article
- Checkpoint activation drives global gene expression changes in Drosophila nuclear lamina mutants.G3 (Bethesda, Md.) · 2022Article
- Drosophila female germline stem cells undergo mitosis without nuclear breakdown.Current biology : CB · 2021Article
- The NEMP family supports metazoan fertility and nuclear envelope stiffness.Science advances · 2020Article
- Survival ofDevelopment (Cambridge, England) · 2020Article
- Nuclear lamina dysfunction triggers a germline stem cell checkpoint.Nature communications · 2018Article
- MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila.Cellular and molecular neurobiology · 2017Article
- Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin.Developmental biology · 2016Article
- Nuclear membrane diversity: underlying tissue-specific pathologies in disease?Current opinion in cell biology · 2015Review
- Networking in the nucleus: a spotlight on LEM-domain proteins.Current opinion in cell biology · 2015Review
- Article
- Molecular simulation investigation on the interaction between barrier-to-autointegration factor or its Gly25Glu mutant and DNA.Journal of molecular modeling · 2014Article
- Ter94/VCP is a novel component involved in BMP signaling.PloS one · 2014Article
- The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular development.Genetics · 2013Article
- Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.Science signaling · 2013Article
- Morphological and color differences between island and mainland populations in the Mexican red rump tarantula, Brachypelma vagans.Journal of insect science (Online) · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear lamina represents a protein network required for nuclear structure and function. One family of lamina proteins is defined by an approximately 40-aa LAP2, Emerin, and MAN1 (LEM) domain (LEM-D) that binds the nonspecific DNA-binding protein, barrier-to-autointegration factor (BAF). Through interactions with BAF, LEM-D proteins serve as a bridge between chromosomes and the nuclear envelope. Mutations in genes encoding LEM-D proteins cause human laminopathies that are associated with tissue-restricted pathologies. Drosophila has five genes that encode proteins with LEM homology. Using yeast two-hybrid analyses, we demonstrate that four encode proteins that bind Drosophila (d)BAF. In addition to dBAF, dMAN1 associates with lamins, the LEM-D protein Bocksbeutel, and the receptor-regulated Smads, demonstrating parallel protein interactions with vertebrate homologs. P-element mobilization was used to generate null dMAN1 alleles. These mutants showed decreased viability, with surviving adults displaying male sterility, decreased female fertility, wing patterning and positioning defects, flightlessness, and locomotion difficulties that became more severe with age. Increased phospho-Smad staining in dMAN1 mutant wing discs is consistent with a role in transforming growth factor (TGF)-beta/bone morphogenic protein (BMP) signaling. The tissue-specific, age-enhanced dMAN1 mutant phenotypes are reminiscent of human laminopathies, suggesting that studies in Drosophila will provide insights into lamina dysfunction associated with disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.