ArticleGenetics2008
The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Modeling open surgery in mice to explore peritoneal damage, carbon dioxide humidification and desmoidogenesis.Pleura and peritoneum · 2019Article
- Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer.International journal of cancer · 2019Article
- Hereditary cancer syndromes as model systems for chemopreventive agent development.Seminars in oncology · 2016Review
- Genetic reconstitution of tumorigenesis in primary intestinal cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Vavien: an algorithm for prioritizing candidate disease genes based on topological similarity of proteins in interaction networks.Journal of computational biology : a journal of computational molecular cell biology · 2011Article
- Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice.International journal of cancer · 2011Article
- Mutation and epigenetic molecular clocks in cancer.Carcinogenesis · 2011Review
- PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling.BMC bioinformatics · 2010Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Familial adenomatous polyposis (FAP) is a human cancer syndrome characterized by the development of hundreds to thousands of colonic polyps and extracolonic lesions including desmoid fibromas, osteomas, epidermoid cysts, and congenital hypertrophy of the pigmented retinal epithelium. Afflicted individuals are heterozygous for mutations in the APC gene. Detailed investigations of mice heterozygous for mutations in the ortholog Apc have shown that other genetic factors strongly influence the phenotype. Here we report qualitative and quantitative modifications of the phenotype of Apc mutants as a function of three genetic variables: Apc allele, p53 allele, and genetic background. We have found major differences between the Apc alleles Min and 1638N in multiplicity and regionality of intestinal tumors, as well as in incidence of extracolonic lesions. By contrast, Min mice homozygous for either of two different knockout alleles of p53 show similar phenotypic effects. These studies illustrate the classic principle that functional genetics is enriched by assessing penetrance and expressivity with allelic series. The mouse permits study of an allelic gene series on multiple genetic backgrounds, thereby leading to a better understanding of gene action in a range of biological processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.