ArticleMolecular biology and evolution2008
Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Chromosome arm-specific patterns of polymorphism associated with chromosomal inversions in the major African malaria vector, Anopheles funestus.Molecular ecology · 2017Article
- Determining the Effect of Natural Selection on Linked Neutral Divergence across Species.PLoS genetics · 2016Article
- Elevated mutation rate during meiosis in Saccharomyces cerevisiae.PLoS genetics · 2015Article
- Genomic signatures of selection at linked sites: unifying the disparity among species.Nature reviews. Genetics · 2013Review
- Recombination modulates how selection affects linked sites in Drosophila.PLoS biology · 2012Article
- Recombination drives vertebrate genome contraction.PLoS genetics · 2012Article
- Recombination rate variation in closely related species.Heredity · 2011Review
- The surprising negative correlation of gene length and optimal codon use--disentangling translational selection from GC-biased gene conversion in yeast.BMC evolutionary biology · 2011Article
- Article
- Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis.Journal of molecular evolution · 2010Article
- The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis.PLoS genetics · 2010Article
- Natural selection shapes nucleotide polymorphism across the genome of the nematode Caenorhabditis briggsae.Genome research · 2010Article
- Conservation of recombination hotspots in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The recombination landscape of the zebra finch Taeniopygia guttata genome.Genome research · 2010Article
- Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates.Genome biology and evolution · 2009Article
- Article
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Abstract
Local rates of recombination positively correlate with DNA sequence diversity in many species. To test whether this relationship stems from mutagenicity of meiotic recombination, studies often look for a similar association between local rates of recombination and sequence "divergence" between species. Because recombination is mutagenic in yeast, I evaluate this assay by testing whether noncoding DNA sequence divergence between Saccharomyces species is related to measures of meiotic double-strand DNA breaks or crossover rates derived from Saccharomyces cerevisiae. Contrary to expectation, I find that sequence divergence is either uncorrelated or negatively correlated with rates of both double-strand break and crossover. Several caveats are mentioned, but these results suggest that mutagenesis from meiotic recombination is not the primary driver of sequence divergence between Saccharomyces species. This study demonstrates that the association between interspecies nucleotide divergence and local recombination rates is not always a reliable indicator of recombination's mutagenicity.
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