ArticleCerebral cortex (New York, N.Y. : 1991)2009
Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset.
Article in Cerebral cortex (New York, N.Y. : 1991), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
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- Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents.Psychopharmacology · 2019Trial
- Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals.PLoS biology · 2017Trial
- Serotonin versus catecholamine deficiency: behavioral and neural effects of experimental depletion in remitted depression.Translational psychiatry · 2015Trial
- Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease.Brain : a journal of neurology · 2014Trial
- Serotonin selectively modulates reward value in human decision-making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- The influence of serotonin on fear learning.PloS one · 2012Trial
- Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies.Clinical drug investigation · 2025Review
- The Orbitofrontal Cortex Underlies Consolidation of Pavlovian Anticipatory Arousal Responses in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Divergent Whole Brain Projections from the Ventral Midbrain in Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Call for a more balanced approach to understanding orbital frontal cortex function.Behavioral neuroscience · 2021Article
- The relationship between monoaminergic gene expression, learning, and optimism in red junglefowl chicks.Animal cognition · 2020Article
- Prefrontal cortex executive processes affected by stress in health and disease.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals.Nature communications · 2018Article
- The neural basis of reversal learning: An updated perspective.Neuroscience · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have shown previously that the inhibitory control functions of the orbitofrontal cortex (OFC) are disrupted by serotonin, but not dopamine depletions. However, both dopamine and serotonin terminals and receptors are present within the OFC and thus the aim of the present study was to determine the differential contributions of these neurotransmitters to orbitofrontal function. OFC and dopamine are involved in the process by which neutral stimuli take on reinforcing properties, by virtue of their prior association with reward, and guide behavior. Thus, we compared the performance of marmosets with dopaminergic or serotoninergic OFC depletions on a test of conditioned reinforcement. To further our understanding of serotonin in behavioral flexibility, the effect of these depletions was also compared on the extinction of a visual discrimination. Monkeys with serotonin depletions of the OFC displayed stimulus-bound responding on both tests of conditioned reinforcement and discrimination extinction suggesting that orbitofrontal serotonin plays a specific role in preventing competing, task irrelevant, salient stimuli from biasing responding. In contrast, monkeys with dopamine depletion were insensitive to conditioned reinforcers and displayed persistent responding in the absence of reward in extinction, a pattern of deficits that may reflect basic deficits in the associative processing of reward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.