ArticleThe Plant cell2008
Type B response regulators of Arabidopsis play key roles in cytokinin signaling and plant development.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers, 1 of them a synthesis that pooled it.
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Who cites it
231 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis.Plant physiology · 2013Pooled it
- Root-sourced 1-aminocyclopropane-1-carboxylic acid modulates development and adaptive responses to salinity in tomato.The Plant journal : for cell and molecular biology · 2026Article
- Selective autophagy receptor VISP1 enhances cytokinin signaling by modulating the Type-A/B ARR feedback loop during root development.Science advances · 2026Article
- A circadian repressor promotes flowering via dual repression: PtTOC suppresses the floral inhibitor PtTFL2 in Pinus tabuliformis.BMC plant biology · 2026Article
- Cytokinin response factor 1 acts as a negative regulator of cytokinin-mediated developmental pathways in Arabidopsis.Planta · 2026Article
- The role of jasmonates in plant root growth and development.Frontiers in plant science · 2026Review
- Root Growth and Leaf Senescence Assays as Physiological Readouts of Cytokinin Response in Arabidopsis thaliana.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Poplar Sex-Determining Gene Directly Affects Tree Growth Through Regulating Cytokinin Signalling Pathway.Plant biotechnology journal · 2025Article
- Identification of BoRR gene family in cauliflower: roles in curd development and salt tolerance.BMC genomics · 2025Article
- Rational Modulation of Plant Root Development Using Engineered Cytokinin Regulators.ACS synthetic biology · 2025Article
- AcRR1 of Agropyron cristatum boosts wheat yield by regulating grain number per spike and heading date.Nature communications · 2025Article
- The role of cytokinin receptors in Arabidopsis thaliana seed development and how they affect the metabolomic profile.Planta · 2025Article
- Root-derived cytokinin regulates Arabidopsis flowering time through components of the age pathway.Plant physiology · 2025Article
- Molecular Characterization of Cytokinin Response Regulator ARR21 inPlant direct · 2025Article
- Transcriptional and phytohormonal responses to simulated animal grazing in Leymus chinensis.Plant cell reports · 2025Article
- Regulatory effects of gibberellin and cytokinin on citrus peel cell wall metabolism.BMC plant biology · 2025Article
- The Overexpression ofPlants (Basel, Switzerland) · 2025Article
- Non-Canonical Inter-Protein Interactions of Key Proteins Belonging to Cytokinin Signaling Pathways.Plants (Basel, Switzerland) · 2025Review
- Article
- Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway.Journal of integrative plant biology · 2025Review
171 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type B Arabidopsis Response Regulators (ARRs) of Arabidopsis thaliana are transcription factors that act as positive regulators in the two-component cytokinin signaling pathway. We employed a mutant-based approach to perform a detailed characterization of the roles of ARR1, ARR10, and ARR12 in plant growth and development. The most pronounced phenotype was found in the arr1-3 arr10-5 arr12-1 triple loss-of-function mutant, which showed almost complete insensitivity to high levels of exogenously applied cytokinins. The triple mutant exhibited reduced stature due to decreased cell division in the shoot, enhanced seed size, increased sensitivity to light, altered chlorophyll and anthocyanin concentrations, and an aborted primary root with protoxylem but no metaxylem. Microarray analysis revealed that expression of the majority of cytokinin-regulated genes requires the function of ARR1, ARR10, and ARR12. Characterization of double mutants revealed differing contributions of the type B ARRs to mutant phenotypes. Our results support a model in which cytokinin regulates a wide array of downstream responses through the action of a multistep phosphorelay that culminates in transcriptional regulation by ARR1, ARR10, and ARR12.
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