ArticleHuman molecular genetics2008
Novel expression and transcriptional regulation of FoxJ1 during oro-facial morphogenesis.
Article in Human molecular genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Dissecting and steering cell dynamics using spatially-informed RNA velocity with veloAgent.Molecular systems biology · 2026Article
- Mucociliary Wnt signaling promotes cilia biogenesis and beating.Nature communications · 2023Article
- FoxO6 regulates Hippo signaling and growth of the craniofacial complex.PLoS genetics · 2018Article
- The link between FOXJ1 expression level in bladder carcinoma and tumor recurrence.Oncology letters · 2018Article
- Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons.Molecular neurobiology · 2017Article
- Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease.Heart failure reviews · 2016Review
- A pituitary homeobox 2 (Pitx2):microRNA-200a-3p:β-catenin pathway converts mesenchymal cells to amelogenin-expressing dental epithelial cells.The Journal of biological chemistry · 2014Article
- Pitx2c is reactivated in the failing myocardium and stimulates myf5 expression in cultured cardiomyocytes.PloS one · 2014Article
- A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome.Human molecular genetics · 2014Article
- Myb promotes centriole amplification and later steps of the multiciliogenesis program.Development (Cambridge, England) · 2013Article
- The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.Development (Cambridge, England) · 2013Article
- RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium.Respiratory research · 2013Article
- Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.The Journal of biological chemistry · 2013Article
- Wnt/β-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV-3.The Journal of biological chemistry · 2013Article
- PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.Investigative ophthalmology & visual science · 2011Article
- Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression.The Journal of biological chemistry · 2011Article
- Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21.Developmental biology · 2010Article
- Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus.Molecular biology of the cell · 2009Article
- The Pitx2c N-terminal domain is a critical interaction domain required for asymmetric morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Proteomic and genomic analysis of PITX2 interacting and regulating networks.FEBS letters · 2009Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Axenfeld-Rieger syndrome (ARS) patients with PITX2 point mutations exhibit a wide range of clinical features including mild craniofacial dysmorphism and dental anomalies. Identifying new PITX2 targets and transcriptional mechanisms are important to understand the molecular basis of these anomalies. Chromatin immunoprecipitation assays demonstrate PITX2 binding to the FoxJ1 promoter and PITX2C transgenic mouse fibroblasts and PITX2-transfected cells have increased endogenous FoxJ1 expression. FoxJ1 is expressed at embryonic day 14.5 (E14.5) in early tooth germs, then down-regulated from E15.5-E17.5 and re-expressed in the inner enamel epithelium, oral epithelium, tongue epithelium, sub-mandibular salivary gland and hair follicles during E18.5 and neonate day 1. FoxJ1 and Pitx2 exhibit overlapping expression patterns in the dental and oral epithelium. PITX2 activates the FoxJ1 promoter and, Lef-1 and beta-catenin interact with PITX2 to synergistically regulate the FoxJ1 promoter. FoxJ1 physically interacts with the PITX2 homeodomain to synergistically regulate FoxJ1, providing a positive feedback mechanism for FoxJ1 expression. Furthermore, FoxJ1, PITX2, Lef-1 and beta-catenin act in concert to activate the FoxJ1 promoter. The PITX2 T68P ARS mutant protein physically interacts with FoxJ1; however, it cannot activate the FoxJ1 promoter. These data indicate a mechanism for the activity of the ARS mutant proteins in specific cell types and provides a basis for craniofacial/ tooth anomalies observed in these patients. These data reveal novel transcriptional mechanisms of FoxJ1 and demonstrate a new role of FoxJ1 in oro-facial morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.