ArticleBiological psychiatry2008
Decreased cognition in children with risk factors for Alzheimer's disease.
Article in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.Neuropsychology review · 2023Pooled it
- Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans.Neuroscience and biobehavioral reviews · 2018Pooled it
- Early Life Epidemiology of Alzheimer's Disease--A Critical Review.Neuroepidemiology · 2015Pooled it
- The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026Article
- Article
- Family history of dementia and brain health in childhood and middle age: a prospective community-based study.European journal of epidemiology · 2024Article
- APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PMBiomolecules · 2023Review
- Ultra-Early Screening of Cognitive Decline Due to Alzheimer's Pathology.Biomedicines · 2023Review
- Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease.Frontiers in human neuroscience · 2023Article
- APOE ε4 influences cognitive decline positively in APP and negatively in PSEN1 mutation carriers with autosomal-dominant Alzheimer's disease.European journal of neurology · 2022Article
- Chronic Status of Serum Albumin and Cognitive Function: A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Neuronal cell death mechanisms in Alzheimer's disease: An insight.Frontiers in molecular neuroscience · 2022Review
- Sex Differences in Cognitive Abilities Among Children With the Autosomal Dominant Alzheimer Disease Presenilin 1 E280A Variant From a Colombian Cohort.JAMA network open · 2021Article
- Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets.Neurobiology of aging · 2020Article
- Dementia risk in women higher in same-sex than opposite-sex twins.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors.eLife · 2019Article
- A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.EBioMedicine · 2019Article
- The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk.International journal of molecular sciences · 2019Review
- Apolipoprotein E Homozygous ε4 Allele Status: A Deteriorating Effect on Visuospatial Working Memory and Global Brain Structure.Frontiers in neurology · 2019Article
- Polygenic Risk Score for Alzheimer's Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life.The American journal of psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe epsilon4 allele of the apolipoprotein E gene (APOE-epsilon4) and a family history (+FH) of Alzheimer's disease (AD) are both risk factors for the development of AD. Although studies to identify a preclinical phase of AD have led to evidence of APOE-epsilon4- and +FH-related differences in brain and cognitive functioning in healthy adults, the relative influence of these factors in children is unknown.
methodsTo investigate this issue, school-age children (n = 109) received standardized achievement tests, the Rey-Osterrieth Complex Figure Test (Copy Condition; RCFT-CC), assessment of family medical history, and buccal swab testing to determine their APOE genotype.
resultsAnalyses revealed that, relative to children without these risk factors, children who possess both an APOE-epsilon4 allele and a +FH of AD and/or significant memory problems (MP) obtained lower scores on nearly every cognitive test administered.
conclusionsFindings suggest that when both AD risk factors are present, cognition may be adversely affected as early as childhood. Thus, risk factors for a disorder of pathological aging (i.e., AD) may have implications for the etiology of certain types of learning difficulties in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.