ArticleBiochimica et biophysica acta2008
Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase.
Article in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Chronic cold exposure causes left ventricular hypertrophy that appears to be physiological.The Journal of experimental biology · 2024Article
- Autophagy is Involved in Cardiac Remodeling in Response to Environmental Temperature Change.Frontiers in physiology · 2022Article
- Cold-Induced Lipoprotein Clearance inFrontiers in cell and developmental biology · 2022Article
- Unraveling the Mystery of Cold Stress-Induced Myocardial Injury.Frontiers in physiology · 2020Review
- Structural alterations in rat myocardium induced by chronic l-arginine and l-NAME supplementation.Saudi journal of biological sciences · 2018Article
- The PPAR pan-agonist bezafibrate ameliorates cardiomyopathy in a mouse model of Barth syndrome.Orphanet journal of rare diseases · 2017Article
- The effects of acute cold exposure on morphology and gene expression in the heart of neonatal chicks.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Heart hormones fueling a fire in fat.Adipocyte · 2013Article
- Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux.Biochimica et biophysica acta · 2012Article
- Very-low-density lipoprotein: complex particles in cardiac energy metabolism.Journal of lipids · 2011Article
- Does long-term metformin treatment increase cardiac lipoprotein lipase?Metabolism: clinical and experimental · 2011Article
- Prenatal hypoxia induces increased cardiac contractility on a background of decreased capillary density.BMC cardiovascular disorders · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The contribution of triacylglycerol to energy provision in the hypertrophied heart, mediated through lipoprotein lipase (LPL) is largely unknown and the contribution of very-low-density lipoprotein (VLDL) receptor to control of LPL presentation at the endothelium is unclear. For isolated perfused rat hearts, cold acclimation (CA) induced volume-overload hypertrophy, with decreased developed pressure (P<0.01), increased end-diastolic volume of the left ventricle (P<0.001) and a loss of contractile reserve in response to dobutamine challenge (P<0.01). Oleate utilisation by perfused hearts was unchanged by CA, however uptake of intralipid emulsion increased 3-fold (P<0.01). CA increased the proportion of lipid deposited in tissue lipids from 10% in euthermic controls to 40% (P<0.01) although the overall contribution of individual lipid classes was unaffected. Cold acclimation significantly increased heparin-releasable LPL (P<0.05) and tissue residual LPL (P<0.01). Western blot analysis indicated preserved expression of proteins coding for SERCA2, muscle-CPT1 and VLDL-receptor following CA, while AMPKalpha2 and phospho-AMPKalpha2 were unaffected. These observations indicate that for physiological hypertrophy AMPK phosphorylation does not mediate the enhanced translocation of LPL to cardiac endothelium.
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