ArticleBrain research bulletin2008
Auditory stimuli enhance MDMA-conditioned reward and MDMA-induced nucleus accumbens dopamine, serotonin and locomotor responses.
Article in Brain research bulletin, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Bimodal Stimulation of the Auditory-Somatosensory System Improves Auditory Sensory Gating Function in Patients with Tinnitus.Journal of the American Academy of Audiology · 2026Trial
- Effects of music therapy as an alternative treatment on depression in children and adolescents with ADHD by activating serotonin and improving stress coping ability.BMC complementary medicine and therapies · 2023Trial
- Taylor Swift versus Mozart: music preferences of C57BL/6J mice.Frontiers in behavioral neuroscience · 2025Article
- Enhancing Psychological Interventions for Post-Traumatic Stress Disorder (PTSD) Treatment with Memory Influencing Drugs.Current neuropharmacology · 2023Review
- Altered brain activity and functional connectivity after MDMA-assisted therapy for post-traumatic stress disorder.Frontiers in psychiatry · 2022Article
- Ventral tegmental area dopaminergic action in music therapy for post-traumatic stress disorder: A literature review.Frontiers in psychology · 2022Review
- Progress and promise for the MDMA drug development program.Psychopharmacology · 2018Review
- Music Affects Rodents: A Systematic Review of Experimental Research.Frontiers in behavioral neuroscience · 2018Article
- Article
- Music and the nucleus accumbens.Surgical and radiologic anatomy : SRA · 2015Review
- Weekend Ecstasy use disrupts memory in rats.Neuroscience letters · 2013Article
- 'Ecstasy' enhances noise-induced hearing loss.Hearing research · 2013Article
- Conditioned place preference and aversion for music in a virtual reality environment.Behavioural processes · 2013Article
- 18-Methoxycoronaridine blocks context-induced reinstatement following cocaine self-administration in rats.Pharmacology, biochemistry, and behavior · 2012Article
- Changes caused by haloperidol are blocked by music in Wistar rat.Journal of physiology and biochemistry · 2012Article
- A fully automated and highly versatile system for testing multi-cognitive functions and recording neuronal activities in rodents.Journal of visualized experiments : JoVE · 2012Article
- Music-induced context preference following cocaine conditioning in rats.Behavioral neuroscience · 2011Article
- Music and methamphetamine: conditioned cue-induced increases in locomotor activity and dopamine release in rats.Pharmacology, biochemistry, and behavior · 2011Article
- Heat increases MDMA-enhanced NAcc 5-HT and body temperature, but not MDMA self-administration.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2010Article
- Behavioral, thermal and neurochemical effects of acute and chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") self-administration.Behavioural brain research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
MDMA (3,4-methylenedioxymethamphetamine), also known as ecstasy, is a popular drug often taken in environments rich in audio and visual stimulation, such as clubs and dance parties. The present experiments were conducted to test the notion that auditory stimulation influences the rewarding effects of MDMA. In Experiment 1, a conditioned place preference (CPP) procedure was conducted in which rats received MDMA (1.5mg/kg, s.c.) in a distinctive environment accompanied by music (65-75dB), white noise (70dB), or no added sound. Animals were pretreated with saline on alternating days in an alternate environment. Results revealed CPP in animals exposed to white noise during MDMA trials. For Experiment 2, rats from Experiment 1 had access to operant levers that delivered intravenous MDMA (0.5mg/kg/inj) or saline (0.1ml) on alternate days in the presence or absence of the same types of auditory stimuli as previously experienced. After three each of MDMA and non-reinforced (saline) sessions, animals were tested for NAcc DA and 5-HT responses to MDMA (1.5mg/kg) or saline under the same stimulus conditions. Findings revealed that NAcc DA and 5-HT increased after an MDMA injection, and both DA and 5-HT were significantly highest in animals exposed to music during the test session. These results indicate that paired sensorial stimuli can engage the same systems activated during drug use and enhance neurochemical and behavioral responses to MDMA administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.