ArticleNeuroscience2008
Sweat gland innervation is pioneered by sympathetic neurons expressing a cholinergic/noradrenergic co-phenotype in the mouse.
Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- A neurocutaneous NaScience advances · 2026Article
- Sympathetic Chain Ganglia in the Female Pig During Prenatal Development: Noradrenergic and Cholinergic Neurons.Current issues in molecular biology · 2026Article
- Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors.Scientific reports · 2024Article
- Frey's syndrome: A review of the physiology and possible role of neurotrophic factors.Laryngoscope investigative otolaryngology · 2021Article
- Cholinergic- rather than adrenergic-induced sweating play a role in developing and developed rat eccrine sweat glands.Experimental animals · 2021Article
- Advillin is a tuft cell marker in the mouse alimentary tract.Journal of molecular histology · 2020Article
- The Nervous System Orchestrates and Integrates Craniofacial Development: A Review.Frontiers in physiology · 2016Review
- Eccrine sweat gland development and sweat secretion.Experimental dermatology · 2015Review
- Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents.Cellular and molecular neurobiology · 2015Article
- Article
- Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract.Frontiers in physiology · 2015Article
- Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis.Dermatology research and practice · 2012Article
- Cellular distribution of chromogranin A in excitatory, inhibitory, aminergic and peptidergic neurons of the rodent central nervous system.Regulatory peptides · 2010Article
- Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties.Autonomic neuroscience : basic & clinical · 2009Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Classic neurotransmitter phenotypes are generally predetermined and develop as a consequence of target-independent lineage decisions. A unique mode of target-dependent phenotype instruction is the acquisition of the cholinergic phenotype in the peripheral sympathetic nervous system. A body of work suggests that the sweat gland plays an important role to determine the cholinergic phenotype at this target site. A key issue is whether neurons destined to innervate the sweat glands express cholinergic markers before or only after their terminals make target contact. We employed cholinergic-specific over-expression of the vesicular acetylcholine transporter (VAChT) in transgenic mice to overcome sensitivity limits in the detection of initial cholinergic sweat gland innervation. We found that VAChT immunoreactive nerve terminals were present around the sweat gland anlage already from the earliest postnatal stages on, coincident selectively at this sympathetic target with tyrosine hydroxylase-positive fibers. Our results provide a new mechanistic model for sympathetic neuron-target interaction during development, with initial selection by the target of pioneering nerve terminals expressing a cholinergic phenotype, and subsequent stabilization of this phenotype during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.