Trial reportGastroenterology2008
Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk.
Trial report in Gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Article
- Insights into Biochemical Sources and Diffuse Reflectance Spectral Features for Colorectal Cancer Detection and Localization.Cancers · 2022Article
- Quantification of gastric mucosal microcirculation as a surrogate marker of portal hypertension by spatially resolved subdiffuse reflectance spectroscopy in diagnosis of cirrhosis: a proof-of-concept study.Gastrointestinal endoscopy · 2021Article
- Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection.Scientific reports · 2021Article
- Novel endoscopic optical diagnostic technologies in medical trial research: recent advancements and future prospects.Biomedical engineering online · 2021Review
- Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia.Clinical and translational gastroenterology · 2020Observational
- Optimizing algorithm development for tissue classification in colorectal cancer based on diffuse reflectance spectra.Biomedical optics express · 2019Article
- Tissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study.Journal of translational medicine · 2019Article
- Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer.BMC cancer · 2018Article
- Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis.Oncotarget · 2017Article
- Are there biological differences between screen-detected and interval colorectal cancers in the English Bowel Cancer Screening Programme?British journal of cancer · 2016Article
- Biophotonic endoscopy: a review of clinical research techniques for optical imaging and sensing of early gastrointestinal cancer.Endoscopy international open · 2015Review
- Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Review
- Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Polarization gating spectroscopy of normal-appearing duodenal mucosa to detect pancreatic cancer.Gastrointestinal endoscopy · 2014Article
- New aspects of modern endoscopy.World journal of gastrointestinal endoscopy · 2014Review
- Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography.Journal of biomedical optics · 2014Article
- Algorithm for automated selection of application-specific fiber-optic reflectance probes.Journal of biomedical optics · 2013Article
- Quantitative physiology and immunohistochemistry of oral lesions.Biomedical optics express · 2013Article
- Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification.Journal of Cancer · 2013Article
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Funding
Abstract
BACKGROUND &
aimsWe previously used a novel biomedical optics technology, 4-dimensional elastically scattered light fingerprinting, to show that in experimental colon carcinogenesis the predysplastic epithelial microvascular blood content is increased markedly. To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo.
methodsWe developed a novel, endoscopically compatible, polarization-gated, spectroscopic probe that was capable of measuring oxygenated and deoxygenated (Dhb) hemoglobin specifically in the mucosal microcirculation through polarization gating. Microvascular blood content was measured in 222 patients from the endoscopically normal cecum, midtransverse colon, and rectum. If a polyp was present, readings were taken from the polyp tissue along with the normal mucosa 10-cm and 30-cm proximal and distal to the lesion.
resultsTissue phantom studies showed that the probe had outstanding accuracy for hemoglobin determination (r(2) = 0.99). Augmentation of microvasculature blood content was most pronounced within the most superficial ( approximately 100 microm) layer and dissipated in deeper layers (ie, submucosa). EIBS was detectable within 30 cm from the lesion and the magnitude mirrored adenoma proximity. This occurred for both oxygenated hemoglobin and DHb, with the effect size being slightly greater for DHb. EIBS correlated with adenoma size and was not engendered by nonneoplastic (hyperplastic) polyps.
conclusionsWe show, herein, that in vivo microvascular blood content can be measured and provides an accurate marker of field carcinogenesis. This technological/biological advance has numerous potential applications in colorectal cancer screening such as improved polyp detection and risk stratification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.