ArticleMolecular cell2008
Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome A in balancing light signaling.
Article in Molecular cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 124 citations in OpenAlex.
- Mechanisms underlying green flower formation.Horticulture research · 2026Article
- Sucrose-activated TOR and phyA signaling alleviates shade-mediated inhibition of leaf development in Arabidopsis.Nature communications · 2026Article
- Assessing the Role of PPKs in Phosphorylating Phytochrome A Using the Protoplast Transient Expression System.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The lowdown on breakdown: Open questions in plant proteolysis.The Plant cell · 2024Review
- Liquid-liquid phase separation of TZP promotes PPK-mediated phosphorylation of the phytochrome A photoreceptor.Nature plants · 2024Article
- Functional dissection of phytochrome A in plants.Frontiers in plant science · 2024Review
- Phytochrome phosphorylation in plant light signaling.Frontiers in plant science · 2024Review
- Two Distinct Molecular Types of Phytochrome A in Plants: Evidence of Existence and Implications for Functioning.International journal of molecular sciences · 2023Review
- Arabidopsis FIN219/JAR1 interacts with phytochrome A under far-red light and jasmonates in regulating hypocotyl elongation via a functional demand manner.PLoS genetics · 2023Article
- Regulation of Plant Photoresponses by Protein Kinase Activity of Phytochrome A.International journal of molecular sciences · 2023Review
- Development and carotenoid synthesis in dark-grown carrot taproots require PHYTOCHROME RAPIDLY REGULATED1.Plant physiology · 2022Article
- COP1 positively regulates ABA signaling during Arabidopsis seedling growth in darkness by mediating ABA-induced ABI5 accumulation.The Plant cell · 2022Article
- Mutual upregulation of HY5 and TZP in mediating phytochrome A signaling.The Plant cell · 2022Article
- The phosphatase/kinase balance affects phytochrome A and its native pools, phyA' and phyA″, in etiolated maize roots: evidence from the induction of phyA' destruction by a protein phosphatase inhibitor sodium fluoride.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Article
- Metabolome and transcriptome analysis of flavor components and flavonoid biosynthesis in fig female flower tissues (Ficus carica L.) after bagging.BMC plant biology · 2021Article
- A LexA-based yeast two-hybrid system for studying light-switchable interactions of phytochromes with their interacting partners.aBIOTECH · 2021Article
- Carotenoid Biosynthesis and Plastid Development in Plants: The Role of Light.International journal of molecular sciences · 2021Review
- Physiological Responses of Cucumber Seedlings to Different Supplemental Light Duration of Red and Blue LED.Frontiers in plant science · 2021Article
- Illuminating the COP1/SPA Ubiquitin Ligase: Fresh Insights Into Its Structure and Functions During Plant Photomorphogenesis.Frontiers in plant science · 2021Review
- Functional roles of E3 ubiquitin ligases in gastric cancer.Oncology letters · 2020Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Fine tuning of light signaling is crucial to plant development. Following light-triggered nuclear translocation, the photoreceptor phytochrome A (phyA) regulates gene expression under continuous far-red light and is rapidly destabilized upon red light irradiation by E3 ubiquitin ligases, including COP1. Here we provide evidence that the light signaling repressors SPA proteins contribute to COP1-mediated phyA degradation and that a COP1/SPA1 protein complex is tightly associated with phyA ubiquitination activity. Furthermore, a phosphorylated phyA form accumulates in the nucleus and preferentially associates with the COP1/SPA1 complex. In contrast, underphosphorylated phyA predominantly associates with the phyA-signaling intermediates FHY3 and FHY1. However, COP1 associates with underphosphorylated phyA in the absence of FHY3 or FHY1, suggesting that phyA associations with FHY3 and FHY1 protect underphosphorylated phyA from being recognized by the COP1/SPA complex. We propose that light-induced phyA phosphorylation acts as a switch controlling differential interactions of the photoreceptor with signal propagation or attenuation machineries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.