ReviewSeminars in immunology2008
Early B cell factor: Regulator of B lineage specification and commitment.
Review in Seminars in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Oncogenic Mutations and Tumor Microenvironment Alterations in Diffuse Large B-Cell Lymphoma With Bulky Disease.Cancer medicine · 2026Article
- Insights into the interplay between stroke and depression through lipid metabolism-related diagnostic genes.Molecular brain · 2026Article
- A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis.JCI insight · 2024Article
- Paired single-cell multi-omics data integration with Mowgli.Nature communications · 2023Article
- Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions.BMC biology · 2023Article
- A mouse model of ZTTK syndrome reveals indispensable SON functions in organ development and hematopoiesis.bioRxiv : the preprint server for biology · 2023Article
- EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas.Frontiers in immunology · 2023Article
- The Characteristics and Survival Potential Under Sub-lethal Stress of Mesenchymal Stromal/Stem Cells Isolated from the Human Vascular Wall.Stem cells (Dayton, Ohio) · 2022Review
- In focus in HCB.Histochemistry and cell biology · 2021Article
- EBF1 is expressed in pericytes and contributes to pericyte cell commitment.Histochemistry and cell biology · 2021Article
- A Single-Cell Transcriptome Profiling of Anterior Kidney Leukocytes From Nile Tilapia (Frontiers in immunology · 2021Article
- On the in vivo origin of human nasal mesenchymal stem cell cultures.Laryngoscope investigative otolaryngology · 2020Article
- A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling.Scientific reports · 2017Article
- Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.Genetic epidemiology · 2015Article
- Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.European journal of human genetics : EJHG · 2015Article
- Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia.Journal of experimental & clinical cancer research : CR · 2015Article
- The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus.Clinical epigenetics · 2015Article
- Computational Modeling of a Transcriptional Switch Underlying B-Lymphocyte Lineage Commitment of Hematopoietic Multipotent Cells.PloS one · 2015Article
- The effect of RA on the chick Ebf1-3 genes expression in somites and pharyngeal arches.Development genes and evolution · 2014Article
- Identification of clinically important chromosomal aberrations in acute myeloid leukemia by array-based comparative genomic hybridization.Leukemia & lymphoma · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
B lymphocytes are generated from hematopoietic stem cells in a series of steps controlled by transcription factors. One of the most important regulators of this process is early B cell factor (EBF). Multiple lines of evidence indicate that expression of EBF is a principle determinant of the B cell fate. In the absence of EBF, progenitor cells fail to express classical markers of B cells, including immunoglobulins. EBF drives B cell differentiation by activating the Pax5 gene and other genes required for the pre-B and B cell receptors. New evidence suggests that expression of EBF in common lymphoid progenitors directs B cell fate decisions. Specification and commitment of cells to the B cell lineage are further established by Pax5, which increases expression of EBF. Recently, it was demonstrated that both EBF and Pax5 contribute to the commitment of cells to the B lineage. Together, these studies confirm that EBF is a keystone in the regulatory network that coordinates B cell lineage specification and commitment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.