ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2008
HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors.
Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee.Bone marrow transplantation · 2026Guideline
- Guideline
- A perspective on the selection of unrelated donors and cord blood units for transplantation.Blood · 2012Guideline
- In silico prediction of nonpermissive HLA-DPB1 mismatches in unrelated HCT by functional distance.Blood advances · 2018Trial
- Novel Scoring System for Ranking Hematopoietic Stem Cell Transplantation.Clinical transplantation · 2024Article
- Permissible HLA mismatches in 9/10 unrelated donor pediatric stem cell transplants using HLA-EMMA: an EBMT Inborn Errors Working Party study.Blood advances · 2024Article
- Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation.Frontiers in immunology · 2022Article
- PIRCHE-II: an algorithm to predict indirectly recognizable HLA epitopes in solid organ transplantation.Immunogenetics · 2020Review
- Exploratory Study of Predicted Indirectly ReCognizable HLA Epitopes in Mismatched Hematopoietic Cell Transplantations.Frontiers in immunology · 2019Article
- HLA epitope mismatch in haploidentical transplantation is associated with decreased relapse and delayed engraftment.Blood advances · 2018Article
- Article
- Identification of high-risk amino-acid substitutions in hematopoietic cell transplantation: a challenging task.Bone marrow transplantation · 2016Article
- Matching inside and outside the HLA molecule in allogeneic hematopoietic stem cell transplantation.Haematologica · 2016Article
- Article
- Identification of a permissible HLA mismatch in hematopoietic stem cell transplantation.Blood · 2014Article
- Predicting alloreactivity in transplantation.Journal of immunology research · 2014Review
- Indirectly Recognized HLA-C Mismatches and Their Potential Role in Transplant Outcome.Frontiers in immunology · 2014Review
- Scoring HLA class I mismatches by HistoCheck does not predict clinical outcome in unrelated hematopoietic stem cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2012Article
- Donor registries and search strategies.Methods in molecular biology (Clifton, N.J.) · 2012Article
- The conundrum of HLA-DRB1*14:01/*14:54 and HLA-DRB3*02:01/*02:02 mismatches in unrelated hematopoietic SCT.Bone marrow transplantation · 2011Article
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Authors and funding
6 authors.
Funding
Abstract
This report addresses the concept that permissible HLA mismatching, that is, mismatches that do not generate an allogeneic response, in hematopoietic stem cell transplantation (HCT) can be determined with structural similarity of polymorphic regions. We have applied the triplet version of a structural algorithm called HLAMatchmaker, which considers short sequences involving polymorphic amino acid residues on the molecular surface as key elements of immunogenic epitopes. The triplet matching effect was analyzed in a National Marrow Donor Program dataset consisting of 744 unrelated hematopoietic cell transplantation cases with 1 HLA-A, -B, or -C mismatch and 1690 fully HLA-A, -B, -C, -DR, or -DQ allele matched cases. In multivariate models adjusting for other significant clinical risk factors, the degree of triplet mismatching did not significantly correlate with patient survival, engraftment, or acute graft-versus-host disease (aGVHD). Other structurally based strategies should be pursued to identify permissible HLA mismatches in HCT.
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