ArticleWorld journal of gastroenterology2008
OB glue paste technique for establishing nude mouse human gastric cancer orthotopic transplantation models.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Xiaotan Sanjie recipe suppressed the oncogenic potential of cancer-associated fibroblaststhe stromal-derived factor 1α/C-X-C chemokine receptor type 4 pathway in gastric cancer.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- A new locoregional mouse model of gastric cancer for identifying probes for fluorescence guided surgery.Surgery · 2025Article
- An orthotopic mouse model of gastric cancer invasion and metastasis.Scientific reports · 2018Article
- 3-bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth.Oncology reports · 2016Article
- Role of RNA-interference-induced zinc finger protein 139 suppression in gastric cancer cell sensitivity to chemotherapeutic agents.Oncology letters · 2015Article
- Bioresponsive antisense DNA gold nanobeacons as a hybrid in vivo theranostics platform for the inhibition of cancer cells and metastasis.Scientific reports · 2015Article
- Characterization of gastric cancer models from different cell lines orthotopically constructed using improved implantation techniques.World journal of gastroenterology · 2012Article
- Serial observations on an orthotopic gastric cancer model constructed using improved implantation technique.World journal of gastroenterology · 2011Article
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14 authors.
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Abstract
aimTo establish nude mouse human gastric cancer orthotopic transplantation models using OB glue paste technique.
methodsUsing OB glue paste technique, orthopic transplantation models were established by implanting SGC-7901 and MKN-45 human gastric cancer cell strains into the gastric wall of nude mice. Biological features, growth of the implanted tumors, the success rate of transplantation and the rate of auto-metastasis of the two models were observed.
resultsThe success rates of orthotopic transplantation of the two models were 94.20% and 96%. The rates of hepatic metastasis, pulmonary metastasis, peritoneal metastasis, lymphocytic metastasis and splenic metastasis were 42.13% and 94.20%, 48.43% and 57.97%, 30.83% and 36.96%, 67.30% and 84.06%, and 59.75% and 10.53%, respectively. The occurrence of ascites was 47.80% and 36.96%.
conclusionOB glue paste technique is easy to follow. The biological behaviors of the nude mouse human gastric cancer orthotopic transplantation models established with this technique are similar to the natural processes of growth and metastasis of human gastric cancer, and, therefore, can be used as an ideal model for experimental research of proliferative metastasis of tumors.
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