Evidence map›Paper›PMID 18719892›Full record

ArticleArchives of microbiology2009

Unusual production of glutathione in Actinobacteria.

Todd Johnson, Gerald L Newton, Robert C Fahey, Mamta Rawat

Open access · greenAbstract read
In one paragraph

Article in Archives of microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. The glutathione pathway is required for biofilm formation inCurrent research in microbial sciences · 2026
    Article
  2. Analysis of Essential Isoprene Metabolic Pathway Proteins inApplied and environmental microbiology · 2023
    Article
  3. Article
  4. Characterization of the GlutathioneMicrobiology spectrum · 2021
    Article
  5. Article
  6. Characterization of genes responsive to osmotic and oxidative stresses of the sugarcane bacterial pathogen Leifsonia xyli subsp. xyli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020
    Article
  7. Article
  8. Poplar phyllosphere harbors disparate isoprene-degrading bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  9. Article
  10. Article
  11. Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  12. Article
  13. Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Todd JohnsonDepartment of Biology, California State University-Fresno, Fresno, CA 93740, USA.
Gerald L Newton
Robert C Fahey
Mamta Rawat
California State University, Fresno · USUniversity of California, San Diego · US

Funding

Supplemental MBRS SCORE at California State Univ, FresnoS06GM061223 · NIGMS · CALIFORNIA STATE UNIVERSITY FRESNO · PI KOVACS, SHIRLEY A · 2000 to 2008
$2.9M
MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETSR01AI049174 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAHEY, ROBERT C · 2000 to 2006
$1.7M
MYCOTHIOL BIOSYNTHESIS AND METABOLISM AS TB DRUG TARGETSR21AI049174 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI FAHEY, ROBERT C · 2003 to 2003
$329k
NIAID NIH HHS AI49174NIAID NIH HHS R01 AI049174NIAID NIH HHS R21 AI049174NIGMS NIH HHS 2S06 GM061223-05A1NIGMS NIH HHS S06 GM061223
6 · The paper itself

Abstract

Most Actinobacteria produce mycothiol as the major thiol. In addition to mycothiol Rhodococcus AD45 generates a substantial level of glutathione possibly using genes acquired in a lateral transfer. Instead of mycothiol, Rubrobacter radiotolerans and Rubrobacter xylanophilus produce glutathione, whose synthesis appears to involve enzymes substantially different from those in other organisms.

Indexed as

ActinobacteriaAmino Acid SequenceBacterial ProteinsCysteineGlutathioneGlycopeptidesInositolMolecular Sequence DataSequence AlignmentBacterial ProteinsCysteineGlutathioneGlycopeptidesInositolmycothiol

Identifiers

PMID18719892
PMCPMC2605195
OpenAlexW2005522808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.