ArticleObesity (Silver Spring, Md.)2008
Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.
Article in Obesity (Silver Spring, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Older individuals with HIV infection have greater memory deficits than younger individuals.Journal of neurovirology · 2013Article
- A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components.Scientific reports · 2013Article
- Amerindians show no association of PC-1 gene Gln121 allele and obesity: a thrifty gene population genetics.Molecular biology reports · 2012Article
- Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.Circulation research · 2011Review
- Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.Nature reviews. Endocrinology · 2009Review
- Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects.Metabolic syndrome and related disorders · 2009Article
- Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants.Endocrine · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ectoenzyme ENPP1 (also termed membrane glycoprotein PC-1 or ENPP1/PC-1) is an inhibitor of insulin-induced activation of the insulin receptor. There is evidence from previous studies that coding variants of ENPP1/PC-1 (K121Q) are associated with type 2 diabetes (T2D) and obesity. Studies in the general Turkish population have demonstrated: unique plasma lipid characteristics, a high prevalence of cardiovascular risk factors, and an increased prevalence of obesity and T2D. We investigated, therefore, the association of ENPP1/PC-1 variants with obesity and T2D in Turkish individuals. The TaqMan allelic discrimination assay was used for genotyping the relationship of ENPP1/PC-1 variants to obesity and T2D in a genetic association study of 1,553 genotyped, randomly selected subjects from the Turkish Heart Study. The K121Q (rs1044498) variant and other previously reported variants (rs997509, rs1799774, rs1044548, rs11964389, rs7754561) were analyzed. In this cohort, the minor allele frequency (MAF) of the K121Q variant was associated with obesity in male, but not in female subjects (male, odds ratio 1.64, 95% confidence interval 1.004-2.698, P = 0.048; female, odds ratio 1.003, 95% confidence interval 0.684-1.471, P = ns). In addition, the previously reported ENPP1/PC-1 "risk haplotype" (Q (rs1044498), delT (rs1799774), and G (rs7754561) alleles) was found to be associated with obesity in male, but not in female, subjects (P = 0.035). In contrast, there was no association of either the K121Q variant or the ENPP1/PC-1 haplotype with T2D. We find evidence that variants of ENPP1/PC-1 are associated with obesity in the male Turkish population; thus, these variants may contribute to the development of the obesity in these individuals.
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