ArticleProceedings of the National Academy of Sciences of the United States of America2008
Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Tailoring baker's yeast Saccharomyces cerevisiae for functional testing of channelrhodopsin.PloS one · 2023Article
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- A Functional KViruses · 2020Article
- Chloroviruses.Viruses · 2019Review
- Article
- Review
- Cotranslational Intersection between the SRP and GET Targeting Pathways to the Endoplasmic Reticulum of Saccharomyces cerevisiae.Molecular and cellular biology · 2016Article
- Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.ACS chemical neuroscience · 2014Article
- A virus-encoded potassium ion channel is a structural protein in the chlorovirus Paramecium bursaria chlorella virus 1 virion.The Journal of general virology · 2013Article
- Helical membrane protein conformations and their environment.European biophysics journal : EBJ · 2013Review
- Potassium ion channels: could they have evolved from viruses?Plant physiology · 2013Review
- Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.Biochimica et biophysica acta · 2013Review
- Using yeast to study potassium channel function and interactions with small molecules.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Tuning the tetraethylammonium sensitivity of potassium channel Kcv by subunit combination.The Journal of general physiology · 2012Article
- Physiology of potassium channels in the inner membrane of mitochondria.Pflugers Archiv : European journal of physiology · 2012Review
- Chloroviruses: not your everyday plant virus.Trends in plant science · 2012Review
- Phycodnavirus potassium ion channel proteins question the virus molecular piracy hypothesis.PloS one · 2012Article
- Membrane anchoring and interaction between transmembrane domains are crucial for K+ channel function.The Journal of biological chemistry · 2011Article
- A TSPO-related protein localizes to the early secretory pathway in Arabidopsis, but is targeted to mitochondria when expressed in yeast.Journal of experimental botany · 2011Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
K(+) channels operate in the plasma membrane and in membranes of organelles including mitochondria. The mechanisms and topogenic information for their differential synthesis and targeting is unknown. This article describes 2 similar viral K(+) channels that are differentially sorted; one protein (Kesv) is imported by the Tom complex into the mitochondria, the other (Kcv) to the plasma membrane. By creating chimeras we discovered that mitochondrial sorting of Kesv depends on a hierarchical combination of N- and C-terminal signals. Crucial is the length of the second transmembrane domain; extending its C terminus by > or = 2 hydrophobic amino acids redirects Kesv from the mitochondrial to the plasma membrane. Activity of Kesv in the plasma membrane is detected electrically or by yeast rescue assays only after this shift in sorting. Hence only minor structural alterations in a transmembrane domain are sufficient to switch sorting of a K(+) channel between the plasma membrane and mitochondria.
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Registered trials
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