ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2008
Liquid in the gastroesophageal segment promotes reflux, but compliance does not: a mathematical modeling study.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers.Journal of gastroenterology · 2014Trial
- The Impact of Magnetic Sphincter Augmentation (MSA) on Esophagogastric Junction (EGJ) and Esophageal Body Physiology and Manometric Characteristics.Annals of surgery · 2023Article
- Magnetic sphincter augmentation: Optimal patient selection and referral care pathways.World journal of gastrointestinal endoscopy · 2019Review
- Studies of abnormalities of the lower esophageal sphincter during esophageal emptying based on a fully coupled bolus-esophageal-gastric model.Biomechanics and modeling in mechanobiology · 2018Article
- Acotiamide Has No Effects on Esophageal Motor Activity or Esophagogastric Junction Compliance.Journal of neurogastroenterology and motility · 2018Article
- A continuum mechanics-based musculo-mechanical model for esophageal transport.Journal of computational physics · 2017Article
- Could the peristaltic transition zone be caused by non-uniform esophageal muscle fiber architecture? A simulation study.Neurogastroenterology and motility · 2017Article
- Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers.Journal of neurogastroenterology and motility · 2016Article
- A fully resolved active musculo-mechanical model for esophageal transport.Journal of computational physics · 2015Article
- Simulation studies of circular muscle contraction, longitudinal muscle shortening, and their coordination in esophageal transport.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial 'acid pocket' in symptomatic GERD patients.Alimentary pharmacology & therapeutics · 2011Article
- Esophagogastric junction distensibility assessed with an endoscopic functional luminal imaging probe (EndoFLIP).Gastrointestinal endoscopy · 2010Article
- Esophagogastric junction distensibility after fundoplication assessed with a novel functional luminal imaging probe.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mechanical force relationships that distinguish normal from chronic reflux at sphincter opening are poorly understood and difficult to measure in vivo. Our aim was to apply physics-based computer simulations to determine mechanical pathogenesis of gastroesophageal reflux. A mathematical model of the gastroesophageal segment (GES) was developed, incorporating the primary anatomical and physiomechanical elements that drive GES opening and reflux. In vivo data were used to quantify muscle stiffness, sphincter tone, and gastric pressure. The liquid lining the mucosa was modeled as an "effective liquid film" between the mucosa and a manometric catheter. Newton's second law was solved mathematically, and the space-time details of opening and reflux were predicted for systematic variations in gastric pressure increase, film thickness, muscle stiffness, and tone. "Reflux" was defined as "2 ml of refluxate entering the esophagus within 1 s." GES opening and reflux were different events. Both were sensitive to changes in gastric pressure and sphincter tone. Reflux initiation was extremely sensitive to the liquid film thickness; the protective function of the sphincter was destroyed with only 0.4 mm of liquid in the GES. Compliance had no effect on reflux initiation, but affected reflux volume. The presence of abnormal levels of liquid within the collapsed GES can greatly increase the probability for reflux, suggesting a mechanical mechanism that may differentiate normal reflux from gastroesophageal reflux disease. Compliance does not affect the probability for reflux, but affects reflux volume once it occurs. Opening without reflux suggests the existence of "gastroesophageal pooling" in the distal esophagus, with clinical implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.