ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2008
Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men.Journal of lipid research · 2009Trial
- Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil.Molecules (Basel, Switzerland) · 2022Review
- Article
- Ezetimibe promotes CYP7A1 and modulates PPARs as a compensatory mechanism in LDL receptor-deficient hamsters.Lipids in health and disease · 2020Article
- Review
- Osteopontin deficiency protects mice from cholesterol gallstone formation by reducing expression of intestinal NPC1L1.Molecular medicine reports · 2017Article
- Quantitation of the rates of hepatic and intestinal cholesterol synthesis in lysosomal acid lipase-deficient mice before and during treatment with ezetimibe.Biochemical pharmacology · 2017Article
- Creosote Bush (Larrea tridentata) Improves Insulin Sensitivity and Reduces Plasma and Hepatic Lipids in Hamsters Fed a High Fat and Cholesterol Diet.Frontiers in pharmacology · 2016Article
- Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse.Biochemical pharmacology · 2014Article
- Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease.Biochemical and biophysical research communications · 2014Article
- Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters.Lipids in health and disease · 2014Article
- New insights into the molecular mechanism of intestinal fatty acid absorption.European journal of clinical investigation · 2013Review
- Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol.European journal of clinical investigation · 2013Review
- Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes.Journal of lipid research · 2012Article
- Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic Fatty liver disease.Journal of lipids · 2012Article
- The chylomicron: relationship to atherosclerosis.International journal of vascular medicine · 2012Article
- Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver.Biochimica et biophysica acta · 2011Article
- Mechanism of resistance to dietary cholesterol.Journal of lipids · 2011Article
- Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.Annual review of physiology · 2011Review
- Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Niemann-Pick C1-like 1 (NPC1L1) facilitates the uptake of sterols into the enterocyte and is the target of the novel cholesterol absorption inhibitor, ezetimibe. These studies used the Golden Syrian hamster as a model to delineate the changes in the relative mRNA expression of NPC1L1 and other proteins that regulate sterol homeostasis in the enterocyte during and following cessation of ezetimibe treatment and also to address the clinically important question of whether the marked inhibition of cholesterol absorption alters biliary lipid composition. In hamsters fed a low-cholesterol, low-fat basal diet, the abundance of mRNA for NPC1L1 in the small intestine far exceeded that in other regions of the gastrointestinal tract, liver, and gallbladder. In the first study, female hamsters were fed the basal diet containing ezetimibe at doses up to 2.0 mg.day(-1).kg body wt(-1). At this dose, cholesterol absorption fell by 82%, fecal neutral sterol excretion increased by 5.3-fold, and hepatic and intestinal cholesterol synthesis increased more than twofold, but there were no significant changes in either fecal bile acid excretion or biliary lipid composition. The ezetimibe-induced changes in intestinal cholesterol handling were reversed when treatment was withdrawn. In a second study, male hamsters were given a diet enriched in cholesterol and safflower oil without or with ezetimibe. The lipid-rich diet raised the absolute and relative cholesterol levels in bile more than fourfold. This increase was largely prevented by ezetimibe. These data are consistent with the recent finding that ezetimibe treatment significantly reduced biliary cholesterol saturation in patients with gallstones.
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