ArticleNucleic acids research2008
Viral AlkB proteins repair RNA damage by oxidative demethylation.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 135 citations in OpenAlex.
- The origins and evolution of the RNA virome in land flora.Molecular plant · 2026Article
- Discovery of the order 'Virus evolution · 2026Article
- Grapevine leafroll-associated virus 3: a global threat to grapevine and wine industries but a gold mine for scientific discovery.Journal of experimental botany · 2025Review
- Genome characterization of a newly discovered grapevine leafroll-associated virus S, in the genus ampelovirus by high-throughput sequencing.Journal, genetic engineering & biotechnology · 2025Article
- Alphaflexiviridae in Focus: Genomic Signatures, Conserved Elements and Viral-Driven Cellular Remodeling.Viruses · 2025Review
- YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.Molecular cell · 2025Article
- How nidoviruses evolved the largest known RNA genomes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Insights into the role of N6-methyladenosine (m6A) in plant-virus interactions.Journal of virology · 2025Review
- Genomic analyses of 238 seed plants reveal the evolutionary mechanisms driving specialization of F3H, ANS, and FLS in flavonoid biosynthesis.Frontiers in plant science · 2025Article
- eIF2Bβ confers resistance to Turnip mosaic virus by recruiting ALKBH9B to modify viral RNA methylation.Plant biotechnology journal · 2024Article
- RNA or DNA? Revisiting the Chemical Nature of the Cenancestral Genome.Journal of molecular evolution · 2024Article
- Elucidating the Subcellular Localization of GLRaV-3 Proteins Encoded by the Unique Gene Block inBiomolecules · 2024Article
- Mixed infection of ITPase-encoding potyvirid and secovirid in Mercurialis perennis: evidences for a convergent euphorbia-specific viral counterstrike.Virology journal · 2024Article
- Methyltransferase-like (METTL) homologues participate inPlant signaling & behavior · 2023Article
- The Roles of N6-Methyladenosine Modification in Plant-RNA Virus Interactions.International journal of molecular sciences · 2023Review
- Plant YTHDF proteins are direct effectors of antiviral immunity against an N6-methyladenosine-containing RNA virus.The EMBO journal · 2023Article
- More than annealing: RNAi is not alone in the fight against plant viruses.The EMBO journal · 2023Article
- AlkB RNA demethylase homologues and NMolecular plant pathology · 2022Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Bacterial and mammalian AlkB proteins are iron(II)- and 2-oxoglutarate-dependent dioxygenases that reverse methylation damage, such as 1-methyladenine and 3-methylcytosine, in RNA and DNA. An AlkB-domain is encoded by the genome of numerous single-stranded, plant-infecting RNA viruses, the majority of which belong to the Flexiviridae family. Our phylogenetic analysis of AlkB sequences suggests that a single plant virus might have acquired AlkB relatively recently, followed by horizontal dissemination among other viruses via recombination. Here, we describe the first functional characterization of AlkB proteins from three plant viruses. The viral AlkB proteins efficiently reactivated methylated bacteriophage genomes when expressed in Escherichia coli, and also displayed robust, iron(II)- and 2-oxoglutarate-dependent demethylase activity in vitro. Viral AlkB proteins preferred RNA over DNA substrates, and thus represent the first AlkBs with such substrate specificity. Our results suggest a role for viral AlkBs in maintaining the integrity of the viral RNA genome through repair of deleterious methylation damage, and support the notion that AlkB-mediated RNA repair is biologically relevant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.