ArticleMolecular biology and evolution2008
Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegans.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Direct full-length RNA sequencing reveals unexpected transcriptome complexity duringGenome research · 2020Article
- Evolution of splicing regulatory networks in Drosophila.Genome research · 2014Article
- Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox.International journal of cell biology · 2013Review
- Co-regulation of alternative splicing by diverse splicing factors in Caenorhabditis elegans.Nucleic acids research · 2011Article
- Global genetic robustness of the alternative splicing machinery in Caenorhabditis elegans.Genetics · 2010Article
- Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans.RNA (New York, N.Y.) · 2009Article
- High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans.Genome biology · 2009Article
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Abstract
Evolutionary studies indicate that a high proportion of alternative splicing (AS) events are species-specific; just 28% of minor-form alternatively spliced exons are conserved between mice and humans. We employed a splicing-sensitive microarray to study the evolution of allele-specific AS in nematodes. We compared splicing levels among five distinct Caenorhabditis elegans lines. Our results indicate that AS is less variable between natural isolates (NIs) from England, Hawaii, and Australia than when compared with mutation accumulation lines (6% vs. 21%, respectively, vary compared with N2). This suggests that strong stabilizing selection shapes the evolution of the ratios of isoforms generated by AS in C. elegans. When we analyzed some of the splicing changes between the NIs, we found examples of changes in both cis and trans that lead to alterations in gene-specific AS. This indicates that both these mechanisms for changing AS are employed along the path toward speciation in nematodes.
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