ArticleMolecular biology and evolution2008
Adaptive evolution in rodent seminal vesicle secretion proteins.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Physiological functions of seminal vesicle secretions in male fertility.Histology and histopathology · 2026Review
- Towards a kingdom of reproductive life - the core sperm proteome.Reproduction (Cambridge, England) · 2025Article
- Multiple genes in the Pate5-13 genomic region contribute to ADAM3 processing†.Biology of reproduction · 2024Article
- Convergent rates of protein evolution identify novel targets of sexual selection in primates.Evolution; international journal of organic evolution · 2024Article
- Editorial: New Insights on Seminal Factors Signaling Female Reproduction in Mammals.Frontiers in veterinary science · 2022Article
- Perspective: Re-defining "Pheromone" in a Mammalian Context to Encompass Seminal Fluid.Frontiers in veterinary science · 2021Review
- Molecular Diversification of the Seminal Fluid Proteome in a Recently Diverged Passerine Species Pair.Molecular biology and evolution · 2020Article
- Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility.International journal of molecular sciences · 2019Article
- Seminal vesicle secretory protein 7, PATE4, is not required for sperm function but for copulatory plug formation to ensure fecundity†.Biology of reproduction · 2019Article
- Socially cued seminal fluid gene expression mediates responses in ejaculate quality to sperm competition risk.Proceedings. Biological sciences · 2017Article
- The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo.Molecular biology and evolution · 2017Article
- Structure and Function of Caltrin (Calcium Transport Inhibitor) Proteins.Biochemistry insights · 2017Review
- Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers.G3 (Bethesda, Md.) · 2016Article
- Article
- Sperm competition risk drives plasticity in seminal fluid composition.BMC biology · 2015Article
- On a matter of seminal importance.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Sexual conflict and seminal fluid proteins: a dynamic landscape of sexual interactions.Cold Spring Harbor perspectives in biology · 2014Review
- Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila.Molecular biology and evolution · 2014Article
- Rates of evolution of hominoid seminal proteins are correlated with function and expression, rather than mating system.Journal of molecular evolution · 2014Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Proteins involved in reproductive fitness have evolved unusually rapidly across diverse groups of organisms. These reproductive proteins show unusually high rates of amino acid substitutions, suggesting that the proteins have been subject to positive selection. We sought to identify seminal fluid proteins experiencing adaptive evolution because such proteins are often involved in sperm competition, host immunity to pathogens, and manipulation of female reproductive physiology and behavior. We performed an evolutionary screen of the mouse prostate transcriptome for genes with elevated evolutionary rates between mouse and rat. We observed that secreted rodent prostate proteins evolve approximately twice as fast as nonsecreted proteins, remarkably similar to findings in the primate prostate and in the Drosophila male accessory gland. Our screen led us to identify and characterize a group of seminal vesicle secretion (Svs) proteins and to show that the gene Svs7 is evolving very rapidly, with many amino acid sites under positive selection. Another gene in this group, Svs5, showed evidence of branch-specific selection in the rat. We also found that Svs7 is under selection in primates and, by using three-dimensional models, demonstrated that the same regions have been under selection in both groups. Svs7 has been identified as mouse caltrin, a protein involved in sperm capacitation, the process responsible for the timing of changes in sperm activity and behavior, following ejaculation. We propose that the most likely explanation of the adaptive evolution of Svs7 that we have observed in rodents and primates stems from an important function in sperm competition.
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