ArticleThe Journal of infectious diseases2008
The impact of steroids given with macrolide therapy on experimental Mycoplasma pneumoniae respiratory infection.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Efficacy of glucocorticoids for the treatment of macrolide refractory mycoplasma pneumonia in children: meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2019Pooled it
- Trial
- Dexamethasone downregulates the systemic cytokine response in patients with community-acquired pneumonia.Clinical and vaccine immunology : CVI · 2012Trial
- Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases.Frontiers in immunology · 2023Review
- Macrolide versus Non-Macrolide in Combination with Steroids for the Treatment of Lobar or SegmentalAntibiotics (Basel, Switzerland) · 2022Article
- Mild encephalitis/encephalopathy with a reversible splenial lesion associated with systemic Mycoplasma pneumoniae infection in North America: a case report.Journal of medical case reports · 2022Article
- Mycoplasma infection and ocular surface diseases: a nationwide cohort study.Scientific reports · 2021Observational
- β-Caryophyllene ameliorates the Mycoplasmal pneumonia through the inhibition of NF-κB signal transduction in mice.Saudi journal of biological sciences · 2021Article
- Prediction model for prolonged fever in patients with Mycoplasma pneumoniae pneumonia: a retrospective study of 716 pediatric patients.BMC pulmonary medicine · 2021Article
- Clinical characteristics of refractory mycoplasma pneumoniae pneumonia in children treated with glucocorticoid pulse therapy.BMC infectious diseases · 2021Article
- Implications for dosing regimen of enrofloxacin administered concurrently with dexamethasone in febrile buffalo calves.Tropical animal health and production · 2020Article
- Assessment of serum sialic acid correlated with C3 in children with Mycoplasma pneumoniae pneumonia.Journal of clinical laboratory analysis · 2020Article
- Low-Dose Corticosteroid Treatment in Children WithFrontiers in pediatrics · 2020Article
- Comparative evaluation of different therapeutic protocols for contagious caprine pleuropneumonia in Himalayan Pashmina goats.Tropical animal health and production · 2019Article
- Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: a case control study.Respiratory research · 2019Article
- Adjunctive corticosteroid therapy for inpatients with Mycoplasma pneumoniae pneumonia.BMC pulmonary medicine · 2017Article
- Effects of methylprednisolone or immunoglobulin when added to standard treatment with intravenous azithromycin for refractory Mycoplasma pneumoniae pneumonia in children.World journal of pediatrics : WJP · 2017Article
- Nonantibiotic Adjunctive Therapies for Community-Acquired Pneumonia (Corticosteroids and Beyond): Where Are We with Them?Seminars in respiratory and critical care medicine · 2016Review
- A Compendium for Mycoplasma pneumoniae.Frontiers in microbiology · 2016Review
- Early Additional Immune-Modulators for Mycoplasma pneumoniae Pneumonia in Children: An Observation Study.Infection & chemotherapy · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSystemic steroids have been advocated in addition to antimicrobial therapy for severe Mycoplasma pneumoniae pneumonia. We evaluated the efficacy of clarithromycin, dexamethasone, and combination therapy for M. pneumoniae respiratory infection.
methodsMice infected with M. pneumoniae were treated with clarithromycin, dexamethasone, combined clarithromycin/dexamethasone, or placebo daily; mice were evaluated at baseline and after 1, 3, and 6 days of therapy. Outcome variables included M. pneumoniae culture, lung histopathologic score (HPS), and bronchoalveolar lavage cytokine, chemokine, and growth factor concentrations.
resultsClarithromycin monotherapy resulted in the greatest reductions in M. pneumoniae concentrations. After 3 days of treatment, combination therapy significantly reduced lung HPS compared with placebo, clarithromycin, and dexamethasone alone, whereas, after 6 days of therapy, clarithromycin alone and combination therapy significantly reduced lung HPS compared with placebo. Concentrations of interleukin (IL)-12 p40, RANTES, macrophage chemotactic protein-1, and cytokine-induced neutrophil chemoattractant were significantly lower in mice treated with clarithromycin alone and/or combination therapy compared with dexamethasone alone and/or placebo; combination therapy resulted in a significantly greater reduction than clarithromycin alone for IL-12 p40 and RANTES.
conclusionsAlthough monotherapy with clarithromycin had the greatest effect on reducing concentrations of M. pneumoniae, combination therapy had the greatest effect on decreasing levels of cytokines and chemokines as well as pulmonary histologic inflammation.
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Registered trials
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