ArticleExperimental lung research2008
CXCR3 ligands contribute to Th1-induced inflammation but not to homing of Th1 cells into the lung.
Article in Experimental lung research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Monocytes and T cells incorporated in full skin equivalents to study innate or adaptive immune reactions after burn injury.Frontiers in immunology · 2023Article
- M1Journal for immunotherapy of cancer · 2020Article
- Increased serum Th2 chemokine levels are associated with bronchopulmonary dysplasia in premature infants.European journal of pediatrics · 2019Article
- Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses AgainstFrontiers in immunology · 2018Article
- CXCR3 modulates obesity-induced visceral adipose inflammation and systemic insulin resistance.Obesity (Silver Spring, Md.) · 2014Article
- Third-party umbilical cord blood-derived regulatory T cells prevent xenogenic graft-versus-host disease.Cytotherapy · 2014Article
- Immunopathogenesis of Staphylococcus aureus pulmonary infection.Seminars in immunopathology · 2012Review
- Pulmonary T cell activation in response to chronic particulate air pollution.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections.PLoS pathogens · 2012Article
- Effect of different interferonα2 preparations on IP10 and ET-1 release from human lung cells.PloS one · 2012Article
- Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells.American journal of respiratory cell and molecular biology · 2012Article
- Type I interferon response to extracellular bacteria in the airway epithelium.Trends in immunology · 2011Review
- The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response.Vaccine · 2011Article
- Innate immunity in the respiratory epithelium.American journal of respiratory cell and molecular biology · 2011Review
- CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications.Cytokine & growth factor reviews · 2011Review
- Participation of CD11c(+) leukocytes in methicillin-resistant Staphylococcus aureus clearance from the lung.Infection and immunity · 2011Article
- Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans.Infection and immunity · 2011Article
- CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa.Mucosal immunology · 2011Article
- Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs.PloS one · 2010Article
- CXC chemokine ligand (CXCL) 9 and CXCL10 are antagonistic costimulation molecules during the priming of alloreactive T cell effectors.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Th1 cells are implicated in numerous pulmonary inflammatory disorders, and adoptive transfer of alloreactive Th1 cells mediates lung injury and inflammation in mice. In response to Th1-mediated immune injury, CXCR3 ligands IP10 and MIG are markedly induced. Because Th1 cells express high levels of CXCR3, their recruitment and activity may be influenced by CXCR3 ligands. To examine the role of CXCR3 ligands, the authors inhibited CXCR3-ligand interaction by 2 approaches: (1) antibody ablation of CXCR3 ligands IP10 (CXCL10/interferon-gamma -inducible 10-kDa protein) and MIG (CXCL9/monokine-induced by interferon-gamma), and (2) use of cxcr3(-/-) mice. Antibody neutralization of IP10 and MIG reduced Th1-cell mediated lung inflammation but did not alter Th1-cell influx in the lung. In contrast, a lack of CXCR3 on host cells had no effect on Th1 cells influx or acute inflammation. In vitro, ablation of endogenous IP10 and MIG inhibited antigen-mediated Th1-cell proliferation. These results suggest that the influx of alloreactive Th1 cells into the lung does not require CXCR3 ligands, but that these chemokines do affect Th1-cell proliferation and activity within the affected tissue. Other CXCR3(+) leukocytes do not contribute to acute alloimmune injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.